amethopterin

Amethopterin is a chemotherapy drug and immune system inhibitor used to treat cancers of the blood, bone, lung, breast, head, and neck. In addition, it can treat rheumatoid arthritis and psoriasis.

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

Methopterin shows the activation and bone resorption function of murine osteoclasts.

Methotrexate-d3diammonium is the deuterated form of Methotrexate diammonium. Methotrexate (Amethopterin) functions as an antimetabolite and antifolate by inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, thereby inhibiting DNA synthesis. It also acts as an immunosuppressant and antineoplastic agent, used in treating rheumatoid arthritis and in researching various cancers, such as acute lymphoblastic leukemia.