alosetron

Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.

Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions.

Alosetron (GR 68755) (Z)-2-butenedioate is a Serotonin 5-HT3 receptor antagonist used for the treatment of irritable bowel syndrome.

Alosetron D3 (GR 68755 D3) Hydrochloride is a deuterium-labeled Alosetron. Alosetron is an antagonist of 5HT3-receptor.

Alosetron D3 (GR 68755 D3) is a deuterium-labeled Alosetron. Alosetron is an antagonist of 5HT3-receptor.

Alosetron (GR 68755) Hydrochloride (1:X) is a potent and highly selective 5-HT3 receptor antagonist with anti-inflammatory effects. Alosetron Hydrochloride (1:X) can be used in the study of irritable bowel syndrome (IBS).

Alosetron-13C-d3 the 13C and deuterated compound of Alosetron. Alosetron has a CAS number of 122852-42-0. Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.

Lurosetron (GR-87442) is the 6-fluoro analogue of Alosetron. It functions as a serotonin 5-HT3 receptor antagonist. Lurosetron inhibits recombinant (rbt) CYP1A2 with an IC50 of 0.1 μM and also inhibits other CYP subtypes, including rbtCYP2C9 and rbtCYP3A4, with IC50 values ranging from 3.5 μM to 16 μM.