alkyne peg4 maleimide

Alkyne-PEG4-maleimide is a PEG-based bifunctional linker designed for the construction of PROTAC molecules, enabling covalent conjugation between ligand moieties via its terminal alkyne and maleimide groups, and facilitating selective protein degradation through ubiquitin–proteasome system recruitment.

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

Sulfo DBCO-PEG4-Maleimide (TEA) is a PROTAC linker that falls under the PEG class. It is utilized in the synthesis of PROTAC molecules. Additionally, Sulfo DBCO-PEG4-Maleimide (TEA) serves as a click chemistry reagent, containing a DBCO group that undergoes a strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules.