adp sodium

6-Bn-ADP (N6-benzyl ADP) sodium is a derivative of Adenosine 5'-diphosphate (ADP) that inhibits ATP hydrolysis. It also suppresses the ATPase activity of the proteins Mortalin, Hsc70, and Hsp70, with Ki values of 86.51 μM, 294.5 μM, and 1612 μM, respectively.

ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported into plastids by a membrane-bound transporter.[3]

Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-ribose in isolated cells and tissues.

NADP sodium salt (Sodium NADP) is a coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions.

MethADP is a specific CD73 inhibitor.

NAADP sodium is a Ca2+ mobilizing second messenger that targets a novel Ca(2+) channel located on acidic organelles and indirectly activates TPC by binding to NAADP-binding proteins (NAADP-BPs) that form part of the TPC complex, which can be used to study cancer and immune dysfunction.F13714 fumarate is used in the study of leukemia.GSK321 is used in the study of leukemia.GSK321 is used in the study of leukemia.

Adenosine 5'-diphosphate sodium salt (ADP sodium salt) is an adenine nucleotide that is phosphorylated into ATP by ATPase. This phosphorylation is a key part of cellular homeostatis as it allows for energy storage and is involved in nucleic acid metabolism. ADP affects platelet activation through its interaction with ADP receptors P2Y1, P2Y12 and P2X1. Upon its conversion to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

2'-Amino-2'-deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide, serving as a structural analog of the purine nucleotide ADP.

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate . It serves as a cofactor in various biological reactions. In addition, the balance between these reduced and oxidized forms plays key roles in diverse cellular functions, including cell survival, the maintenance of redox status, and intracellular signaling. For example, binding of NADP+ to β-subunits of Kv channels activates ion transport, whereas NADPH stabilizes channel inactivation. NADP+ is biosynthesized from NAD+ by NAD kinase, with ATP as the phosphoryl donor.

Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a metabolite of nicotinamide adenine nucleotide (NAD+), which is widely present in organisms.Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a potent intracellular Ca2+ permeable cation TRPM2 channel activator that also induces autophagy.)

Deoxyadenosine diphosphate sodium is a diphosphate nucleoside featuring deoxyadenosine as its nucleoside component. It plays a role in the synthesis and repair of DNA. Deoxyadenosine diphosphate sodium acts as an inhibitor of polynucleotide phosphorylase, thereby interfering with the polymerization of ADP and CDP.

2'-Deoxy-NAD+ sodium is the sodium salt form of 2'-Deoxy-NAD+. It acts as a non-competitive inhibitor of NAD+ with a Ki of 32 μM. Additionally, '2'-Deoxy-NAD+ sodium can be utilized as a substrate for studying ADP-ribosyltransferase reactions.

8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium)) is a derivative of NAD+, which functions as a signaling molecule and enzyme cofactor. This compound is utilized in screening gatekeeper mutations of PARP1 (poly[ADP-ribose] polymerase 1) that are sensitive to analogs.

8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+. It is utilized for screening analog-sensitive gatekeeper mutations in poly (ADP-ribose) polymerase 1 (PARP1) and for synthesizing cyclic ADP-ribose (cADPR) derivatives.

Adenosine-5'-O-diphosphoribose phosphate sodium is a structural analog of NADPH and acts as an HMG-CoA reductase inhibitor. It inhibits microsomal HMG-CoA reductase with an apparent Ki value of 550 μM at low thiol concentrations.

8-Br-cADPR (8-Bromo-Cyclic ADP-Ribose) sodium salt is an antagonist of cyclic adenosine diphosphate (ADP)-ribose (cADPR) and the TRPM2 ion channel. It can alleviate kidney injury and reduce the expression of caspase-3 and TRPM2.

5'-XDP sodium (Xanthosine 5'-diphosphate sodium) is an ADP analogue that plays a role in ribosome synthesis.

3'-Amino-3'-deoxyadenosine-5'-O-diphosphate sodium is an amine-modified nucleotide that can be utilized in the synthesis of other active compounds. Its coumarin-labeled derivative exhibits significant fluorescence changes when interacting with myosin, effectively mimicking the function of natural ADP.

8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5) is a cis isomer of dGTP, characterized as an 8-bromoguanosine nucleotide. This compound is hydrolyzed by the enzyme hMTH1 protein. It inhibits dGTP-activated ADP reduction, exhibiting a Ki value of 56 μM. During DNA synthesis, 8-Br-dGTP sodium presents no significant genotoxicity or mutagenic potential.

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) sodium is a fluorescent analog of NAD, serving as a substrate for bacterial toxins that catalyze the G-ADP ribosylation of signal-transduction G proteins. Additionally, Nicotinamide 1,N6-ethenoadenine dinucleotide sodium can be used as a fluorescent substrate in the study of ADP ribosylation reactions.

8-PIP-NAD+ (sodium) (8-Piperidino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+. It is utilized for the detection of Poly(ADP-ribose) Polymerase (PARP) target proteins. Additionally, 8-PIP-NAD+ (sodium) serves as a synthetic intermediate for cyclic ADP-ribose (cADPR) derivatives.