acanthamoeba

CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).

Hexamidine exhibits amoebicidal activity and is applicable in the study of Acanthamoeba keratitis (Acanthamoebakeratitis).

Hexamidine diisethionate is an antimicrobial agent targeting Acanthamoeba protozoa. It shows promise for research into ocular infectious diseases such as Acanthamoeba keratitis.

Propamidine isethionate is an agent in the diamidine class with potent antibacterial and antiprotozoal properties. It is a critical reagent in the research and treatment of Acanthamoeba keratitis. Propamidine exerts its effects by binding to DNA and interfering with nucleic acid synthesis in pathogens.

FFK29 is a synthetic class II HDACi (Histone deacetylase inhibitors) which have have recently emerged as novel therapeutic options for treating various protozoan and parasitic diseases. While these HDACi demonstrated a negligible effect on the viability of mature cysts, Acanthamoeba encystation was significantly inhibited by these HDACi. In conclusion, these synthetic HDACi demonstrated potent amoebicidal effects and inhibited the growth and encystation of Acanthamoeba, thus highlighting their enormous potential for further development.

Hexamidine-d12 is the deuterium-labeled version of Hexamidine. It exhibits amoebicidal activity and can be utilized in research related to Acanthamoeba keratitis (Acanthamoebakeratitis).