T7477

Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias.

D-685, a prodrug of D-520, demonstrates enhanced anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model compared to its parent compound D-520. It effectively reduces the buildup of human α-synuclein (α-syn) protein and readily penetrates the brain [1].

Diaporthein B, a highly oxidized pimarane diterpene, demonstrates significant activity against M. tuberculosis with a MIC of 3.1 μg/mL and exhibits IC50 values ranging from 1.5-3 μM/L against HCT 116 and LoVo colon cancer cells [1].

Antifungal agent 47 (compound 3b) exhibits potent and broad-spectrum fungicidal properties, notably inhibiting respiration and adenosine 5′-triphosphate synthesis, demonstrating its potential as an effective fungicide [1].

Antiparasitic Agent-14 is a potent antiparasitic compound with demonstrated cytotoxicity and antiparasitic activity, effectively inhibiting the growth of trypomastigote and amastigote forms [1].

Neuraminidase-IN-16 (Compound 43b) serves as a potent inhibitor of neuraminidase, demonstrating IC50 values of 0.031, 0.15, 0.25, 0.60, 0.63, and 10.08 μM against neuraminidase from H5N1, H5N8, H1N1, H3N2, H5N1–H274Y, and H1N1–H274Y strains, respectively [1].

Antibacterial agent 139 exhibits antibacterial activity specifically targeting Gram-positive bacteria, including resistant strains such as MRSA (anti-MRSA), VISA (anti-VISA), and LRSE (anti-LRSE). It operates by depolarizing the bacterial cell membrane [1].

ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic arch and aorta, along with decreasing plasma ceramide concentrations and oxidized LDL (Ox-LDL) levels [1].

JNJ-28583113 is a brain-penetrant TRPM2 antagonist that induces phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death. It inhibits microglia response to pro-inflammatory stimuli, used in the study of neurological diseases.