T7417

Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.

MOCPAC is an HDAC1-specific substrate [1].

Crotonyl-CoA, an intermediate in the fermentation of butyric acid as well as in the metabolism of lysine and tryptophan, plays a crucial role in the metabolism of fatty acids and amino acids [1].

Acetoacetyl coenzyme A sodium, a pivotal endogenous metabolite, exhibits a K m of 1.10 mM at pH 7.5 and plays a crucial role in the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) [1] [2].

JB170 is a highly efficient and specific Aurora A degradator (DC50 = 28 nM). The PROTAC is composed of Alisertib and Thalidomide, with an EC50 value for AURORA-A that is ten times that of AURORA-B. It induces S-phase arrest in cell growth and inhibits the non-catalytic function of the AURORA-A kinase.

Pseudouridine-5'-triphosphate (Pseudo-UTP) is widely known for its role in polymerase-mediated RNA synthesis, frequently surpassing uridine in unmodified mRNAs due to improved nuclease stability, immunogenicity, and translational properties.

Modified MMAF, a cytotoxin for antibody-drug conjugates (ADC), facilitates the synthesis of ADCs tailored for targeted cancer research [1].

Glembatumumab vedotin (CDX-011) is an antibody-drug conjugate (ADC) that targets cancer cells expressing transmembrane glycoprotein NMB (GPNMB). Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC).

1-Heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine, an endogenous metabolite present in blood, is utilized in research on pregnancy and sepsis [1] [2] [3].

Avatrombopag-D8 is a deuterated compound of Avatrombopag. Avatrombopag (T7417) has a CAS number of 570406-98-3. Avatrombopag (T7417) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.