T7381

TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with a Ki value of 0.29 μM.

H-Ile-Pro-Pro-OH hydrochloride, a tripeptide derived from dairy products, consists of one isoleucine (Ile) and two prolines (Pro). H-Ile-Pro-Pro-OH hydrochloride inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM. H-Ile-Pro-Pro-OH hydrochloride exhibits antihypertensive effects.

Haemanthamine hydrochloride, a crinine-type alkaloid derived from Amaryllidaceae plants, exhibits potent anticancer properties. It acts by targeting ribosomes, thereby inhibiting protein biosynthesis during the translation elongation stage. Additionally, this compound demonstrates pro-apoptotic, antioxidant, antiviral, antimalarial, and anticonvulsant activities [1] [2].

Cis-Lomibuvir (cis-VX-222), a cis-isomer of Lomibuvir, is a selective non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase (RdRp), targeting thumb pocket 2 with a dissociation constant (Kd) of 17 nM. It exhibits an EC50 of 5.2 nM against the 1b/Con1 HCV subgenomic replicon, demonstrating a preference for inhibiting elongative RNA synthesis over de novo-initiated RNA synthesis.

TMC-205, a natural fungal metabolite, exhibits antiproliferative effects against cancer cell lines and functions as a transcriptional up-regulator of the SV40 promoter [1].

Fusafungine, known commercially as Bioparox, Fusaloyos, and Locabiotal, serves as a potent antibiotic and anti-inflammatory agent effective in oral administration. It shows promise for research related to upper respiratory airways disease (URAD)[1][2].

SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1] [2] [3].

Homocarnosine TFA, a unique dipeptide of γ-aminobutyric acid (GABA) and histidine found in the brain, acts as an inhibitory neuromodulator synthesized from GABA within neurons. It exhibits anticonvulsant effects [1], and possesses antioxidant and anti-inflammatory properties, prevents DNA damage, and inhibits the formation of advanced glycation end-products [2].