T7327

7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).

GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.

MMV688845 is a bactericidal nontuberculous mycobacteria (NTM) RNA polymerase inhibitor that exhibits anti-tuberculosis efficacy and is effective against Mycobacterium abscessus.

SERT-IN-2, a potent SERT inhibitor (IC 50 = 0.58 nM), exhibits promising efficacy as an anti-depressant. It demonstrates a favorable bioavailability of 83.28% in rats and has the ability to cross the blood-brain barrier.

CamA-IN-1 is a Clostridioides difficile -specific DNA adenine methyltransferase (CamA) inhibitor. CamA-IN-1 has inhibitory for CamA with IC 50 and K d values of 0.4 μM and 0.2 μM, respectively. CamA-IN-1 can be used for the research of Clostridioides difficile infections (CDI) .

BTK-IN-22, a BTK inhibitor (IC 50: 0.9 nM), also exhibits inhibition against BLX and BMX with IC 50 values of 1.4 and 1.2 nM, respectively. Demonstrating enhanced kinase selectivity, BTK-IN-22 outperforms Ibrutinib in this regard [1].

BTK-IN-23 is a BTK inhibitor with an IC50 value of 12.8 nM, demonstrating kinase selectivity superior to Ibrutinib [1]. It effectively inhibits BLX and BMX, with IC50 values of 35.6 nM and 5.7 nM, respectively.

MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis.