T6299

GDC-0152 is a potent inhibitor of IAPs.

AS1134900 is a highly selective, non-competitive, metabotropic NADP+-dependent malic enzyme 1 (ME1) inhibitor.

Mpro/PLpro-IN-1 (Compound 29) is a dual-acting inhibitor of SARS-CoV-2 protease, displaying micromolar inhibition of Mpro (IC50: 1.72 μM) and submicromolar inhibition of PLpro (IC50: 0.67 μM).

Trandolapril (RU44570) hydrochloride is a non-mercapto precursor hydrolyzed to active diacetyl (Trandolapril hydrochlorideat) and has been investigated for the treatment of hypertension, congestive heart failure, and myocardial infarction.

IMB-26 is an HCV inhibitor (EC50: 2.1 μM) and has shown potent anti-HCV effects.

α-Glucosidase-IN-10 (compound 13) is a potent α-glucosidase inhibitor with an IC50 of 92.7 μM, useful for studying type II diabetes.

BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].

10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G(1)-S, disrupts repair of cells damaged by radiation, and induces apoptosis.

PI3K/AKT-IN-1 is a dual PI3K and AKT inhibitor with anti-cancer activity. It inhibits PI3Kγ, PI3Kδ, and AKT, suppressing the PI3K/AKT pathway and inducing caspase 3-dependent apoptosis, suitable for cancer research.

COX-2/15-LOX-IN-1 (Compound 14) is a dual inhibitor of COX-2 and 15-lipoxygenase (15-LOX) with IC50 values of 10.65 μM for COX-1, 0.075 μM for COX-2, and 2.98 μM for 15-LOX, exhibiting an anti-inflammatory effect.

Germination-IN-1 (compound 11) is a potent germination inhibitor with an IC50 of 4 μM, demonstrating significant anti-germination effects, with a germination rate of 14%.