T6228

Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.

PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells.

Enbezotinib is an inhibitor of RET autophosphorylation and can be used in cancer research.

Antifungal agent 17 showed good antifungal activity against B. cinerea (EC50: 2.86 μg/mL).

ADAMTS-5-IN-3 is a highly efficient inhibitor of ADAMTS-5 and ADAMTS-4, useful for studying diseases mediated by these enzymes.

DDO-02005 is a potent inhibitor of the Kv1.5 calcium channel (IC50: 0.72 μM).DDO-02005 exhibits good anti-fibrillation effects in a CaCl2-ACh atrial fibrillation rat model and is effective against anti-aconitine-induced arrhythmias.

Anti-inflammatory agent 21 (compound 9o) is a low cytotoxic, orally active anti-inflammatory agent that targets NO (IC50: 0.76 μM). It accumulates ROS and inhibits the NF-κB/MAPK signaling pathway to exert anti-inflammatory effects, showing beneficial effects on cartilage destruction and inflammatory cell infiltration in a rat model of arthritis.

HIV-1 inhibitor-42 (compound 5b) is a potent inhibitor of HIV-1 with an IC50 of 0.06 μM. It inhibits HIV-1 RT RNA-dependent DNA polymerase with an IC50 of 0.518 μM and DNA-dependent DNA polymerase with an IC50 of 0.072 μM.

AD013 is a dual cACE and NEP inhibitor. AD013 is a C-domain selective ACE inhibitor of lenopril-tryptophan synthesis. AD013 has the potential to provide potent anti-hypertensive and cardioprotective effects.

Irinotecan-D10 is the deuterated form of Irinotecan (T6228) ( (+)-Irinotecan), which acts as an inhibitor of topoisomerase I and is utilized in research related to colon and rectal cancers.