T6045

Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.

AChE/hCA I/II-IN-1 (Compound 6) is a potent AChE/Hca inhibitor with IC50 values of 22.21, 60.79, and 66.64 nM for AChE, Hca Ⅰ, and Hca Ⅱ. AChE/hCA I/II-IN-1 can be used in glaucoma, Alzheimer's disease, and diabetes research[1].

MoTP, a specific platelet-activating factor receptor antagonist, induces melanocyte ablation and is utilized in cancer research.

PCAF-IN-2 is an epigenetic modulator and a potent PCAF (KAT2B) inhibitor. It regulates gene transcription via histone acetylation, used for cancer and inflammation research.

TrxR-IN-3 (Compound 2c) is an effective TrxR inhibitor that exhibits strong antiproliferative activities against five human cancer cell lines, particularly breast tumor cells. It increases ROS levels, induces apoptosis by regulating apoptosis-related protein expression in breast cancer cells, and promotes autophagosome and autolysosome formation by enhancing LC3-II and Beclin-1 expression and reducing LC3-I and p62 protein expression [1].

NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.

Antibacterial agent 65 is a potential antimicrobial agent and antioxidant agent.

ARN726 is a potent inhibitor of NAAA (N-acylethanolamine acid amidase) with an IC 50 of 0.073 μM which decreases the motivation for alcohol in a dose-dependent manner [1] [2].

COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor with potential applications in inflammation disease research[1].

Compound 34e (NS2B/NS3-IN-4) is an allosteric inhibitor of the DENV2 and ZIKV NS2B/NS3 proteases, exhibiting IC50 values of 0.69 µM for DENV2 and 1.04 µM for ZIKV NS2B/NS3 proteases [1].

Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity, exhibiting cytotoxicity in HepG2 cells [1].