T3941

Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity.

Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD).

ACAT-IN-10 dihydrochloride is a compound that serves as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT).ACAT-IN-10 dihydrochloride effectively hampers NF-κB mediated transcription, albeit to a lesser extent.

ACAT-IN-5 (example 19) is an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) that effectively suppresses NF-κB-mediated transcription.

ACAT-IN-8 (example 206) is a compound that inhibits acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation, and also inhibits NF-κB-mediated transcription.

ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB.

ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription.

ACAT-IN-4 hydrochloride (Example 208) is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) in its hydrochloride salt form, effectively hindering NF-κB mediated transcription.

ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription.

Leptin (93-105), human, is a peptide fragment consisting of amino acids 93 to 105 from the human leptin protein. Leptin, a peptide hormone of 167 amino acids, is primarily synthesized by adipocytes and coordinates metabolic adaptations to fasting within the central nervous system.

Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively; its IC50 values against NfENO and TbENO are 0.14 μM and 2.1 μM, respectively. Hex exhibits antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites, and Plasmodium berghei ANKA strain, and also shows certain antitumor effects against intracranial tumors.