T2892

TAN-420C is an antibiotic isolated from Streptomyces hygroscopicus with antitumour activity.

TAS-117, a PKB/Akt inhibitor, is used potentially for the treatment of solid tumors.

TASP0376377 is a potent antagonist of CRTH2.

TASP0390325 is an orally active and high affinity arginine pressin receptor 1B (V1B receptor) antagonist that shows antidepressant and anxiolytic activity in animal studies and blocks V1B receptors in the anterior pituitary gland in vivo.

TASP0433864 is a positive allosteric modulator of metabotropic glutamate 2 receptor with EC50 values of 199 and 206 nM at human and rat mGlu2 receptors, respectively, without exerting agonist activity at rat mGlu2 receptor.