T2639

LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including pepsin, cathepsin D, or renin.

3α,21-Dihydroxy-5α-pregnan-20-one (5alpha-THDOC) is a neurosteroid, a gamma-aminobutyric acid (GABAA) modulator, which is used in the study of neurological disorders such as Alzheimer's disease.

5-Methylurapidil is an alpha1A-adrenoceptor antagonist.

6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.

7DG is a selective inhibitor of protein kinase R (PKR).