T2169

Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. It also inhibits cytidine deaminase (Ki: 2 μM, in a cell-free assay).

(R)-Lisofylline ((R)-Lisophylline) is an inhibitor of lysophosphatidic acid acyltransferase (IC50 = 0.6 µM) that interrupts IL-12 signaling-mediated STAT4 activation, making it useful for studies on the treatment of type 1 diabetes and autoimmune disorders.

Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3].

CC-17369 (7-Hydroxy pomalidomide) hydrochloride functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon protein. It can be linked via a linker to a target protein ligand to form a PROTAC.

CRBN ligand-446 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that is used to recruit the cereblon protein. It can be linked via a linker to a target protein ligand to form a PROTAC.

CRBN ligand-504 is an E3 ubiquitin ligase cereblon (CRBN) ligand used for recruiting cereblon proteins. It can be attached to a target protein ligand via a linker to form a PROTAC.

trans-4-Cyanocyclohexane-1-carboxylic acid is a PROTAC linker used in the synthesis of PROTAC molecules.

Ethyl 7-aminoheptanoate hydrochloride is a PROTAC linker used in the synthesis of PROTAC molecules.

Ethyl 4-oxobutanoate is a PROTAClinker utilized in the synthesis of PROTAC molecules.

CRBN ligand-431 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed to recruit cereblon proteins. CRBN ligand-431 can be linked to a target protein ligand via a linker to form a PROTAC.

PROTACHIF-1αdegrader-2 is a highly efficient and selective PROTAC degrader targeting HIF-1α. It facilitates the degradation of HIF-1α via the ubiquitin-proteasome pathway by promoting the formation of the HIF-1α/VHL ternary complex. This compound inhibits the proliferation, migration, and colony formation of HeLa cells while inducing apoptosis (apoptosis). Additionally, PROTACHIF-1αdegrader-2 reduces the expression of p-MEK and p-AKT in the MAPK and PI3K/AKT pathways. It is useful for cervical cancer research.

CRBN ligand-778 is an E3 ubiquitin ligase cereblon (CRBN) ligand, employed to recruit cereblon proteins. It can be linked via a linker to a target protein ligand to form a PROTAC.

4-(Aminomethyl)bicyclo[2.2.2]octane-1-carboxylic acid is a PROTAC linker used in the synthesis of PROTAC molecules.

NVP-DPP728 is a potent, reversible, nitrile-dependent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an inhibition constant (K i) of 11 nM for human DPP-IV amidolytic activity. By inhibiting the degradation of glucagon-like peptide-1 (GLP-1), NVP-DPP728 enhances insulin release following glucose intake, making it useful for diabetes research [1].

CRBN ligand-213 is an E3 ubiquitin ligase cereblon (CRBN) ligand, utilized for the recruitment of the cereblon protein. It can be linked to a target protein ligand via a linker to form a PROTAC.

Benzyl (6-aminohexyl)carbamate hydrochloride is a PROTAC linker used in the synthesis of PROTAC molecules.

CRBN ligand-743 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) and is used to recruit cereblon proteins. It can be linked to target protein ligands via a linker to form PROTAC.

CRBN ligand-849 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed to recruit cereblon proteins. It can be linked to a target protein ligand via a linker to form PROTAC.

3-(Piperazin-1-yl)propan-1-ol is a PROTAC linker used in the synthesis of PROTAC molecules.

The compound '(9H-Fluoren-9-yl)methyl (2-bromoethyl)carbamate' is a PROTAC linker used in the synthesis of PROTAC molecules.

4-Chlorobutyronitrile is a PROTAC linker used in the synthesis of PROTAC molecules.

CRBN ligand-609 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed to recruit cereblon proteins. It can be linked via a linker to a target protein ligand to form a PROTAC.

E3LigaseLigand-linker Conjugate 213 is a compound that serves as an E3 ubiquitin ligase CRBN ligand-linker conjugate (E3ligaseligand-linker conjugate). This conjugate can be utilized in the synthesis of PSP-0119.

4-(Azetidin-3-yl)piperazin-2-one hydrochloride is a PROTAC linker that serves in the synthesis of PROTAC molecules.