T2168

2-NP is a STAT1 enhancer.

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research.

CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.

A 68930 hydrochloride is a selective dopamine D1 receptor agonist that ameliorates Aβ1–42-induced cognitive impairment and neuroinflammation in mouse models, highlighting its relevance to Alzheimer’s disease research, and at concentrations of 10–50 μg/mL also inhibits gastric H⁺/K⁺-ATPase activity comparably to omeprazole, supporting multifunctional pharmacological investigations.

Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity, which is also a CYP2D6 probe substrate [1] [2].

CD 1530 is a selective and potent RARγ agonist (Kd:150 nM) with potential anticancer activity, shows insecticidal activity against Cryptobacterium hidradii nematodes, and can be used to study oral carcinogenesis.

Conoidin A is a cell-permeable inhibitor of the T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for research on ischaemic heart disease.