T2048

LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.

Carbobenzoxyphenylalanine (NSC-402059) is a thermolysin inhibitor.

4-Isopropylbenzoic acid (Cumic acid) is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive mushroom tyrosinase inhibitor.

Benzalphthalide (NSC-2824) is a chemical compound with anti-HIV activity.

Maytansine derivative M24 is a drug-linker conjugate used in the production of the antibody-drug conjugate (ADC), specifically ADC REGN5093-M114.

Tubulin inhibitor 49 (Compound 18) is a tubulin polymerization inhibitor (IC50 = 48 μM) that disrupts the cellular microtubule network, arresting the cell cycle at G2 phase. It exhibits toxicity toward HeLa cells (IC50 = 8.8 μM).

Antagonist G is an anticancer peptide and is also a broad spectrum neuropeptide growth factor antagonist.

AS2690168 hydrochloride is an orally active inhibitor of RANKL signaling that can suppress RANKL-induced osteoclastogenesis in RAW264 cells. AS2690168 is applicable in research related to pathological bone resorption.

21H7 is a selective inhibitor of the Wnt/b-catenin pathway. It significantly suppresses the growth of HF and effectively inhibits the proliferation of breast and colon cancer cells.

(+)-Mcl-1 inhibitor 21 (Example 1-37) is a chemical compound that acts as an Mcl-1 inhibitor with an IC50 value of 172 nM. It demonstrates pro-apoptotic and antiproliferative activities in SUDHL5 and SUDHL10 cell lines, making it useful for cancer research.

N,N-Diethylpentylone hydrochloride is a psychoactive substance.

GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.

Acth (1-4) is the ACTH N-terminal tetrapeptide.

Lu AF90103 (Compound 42e) is the methyl ester prodrug of compound 42d, capable of crossing the blood-brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, with an efficacy of 24% and an EC50 value of 78 nM. Lu AF90103 plays a significant role in neuropsychiatric disorder research.

ER ligand-8 is a ligand of the estrogen receptor (Estrogen Receptor/ERR) and can be used for the synthesis of the PROTAC molecule ERD-1233.

CEE321 is an effective pan-JAK inhibitor with an IC50 of 54 nM. It effectively inhibits biomarkers associated with atopic dermatitis.

Adenophostin A is a potent agonist of inositol trisphosphate (IP3) receptors, binding with high affinity to these receptors and effectively stimulating the release of calcium ions (Ca2+).

Acth (1-4) acetate is the ACTH N-terminal tetrapeptide.

L-Methionylglycine is an agent of the dipeptide.

ECI830 is a highly potent and selective oral small-molecule CDK2 inhibitor. By inhibiting CDK2 activity, ECI830 induces G1/S phase cell cycle arrest, thereby blocking DNA replication and tumor proliferation. ECI830 is suitable for use in studies of HR+/HER2- breast cancer and tumors with CCNE1 amplification.

HDAC6-IN-52 (EX.1) is a potent HDAC6 inhibitor, achieving a 100% inhibition rate at a concentration of 10 μM. It plays a significant role in central nervous system disorders, including neurodegenerative diseases such as Alzheimer's disease and progressive supranuclear palsy.

AB8939 is a potent small-molecule inhibitor of microtubule/tubulin polymerization, exhibiting antitumor activity (with tumor cell proliferation inhibition IC50≤10 nM). It effectively circumvents resistance mechanisms mediated by P-glycoprotein and myeloperoxidase. AB8939 can induce G2/M phase cell cycle arrest and apoptosis.

Ac-EEVC-OH is a linker utilized in the synthesis of ADC molecules.

CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.