T2012

Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM).

(+)-O-Acetyl-L-mandelic Acid is an aromatic compound suitable for biochemical experiments and drug synthesis research.

L-Carnitine hydrochloride ((R)-Carnitine hydrochloride) is a highly polar small zwitterionic molecule that functions as an essential cofactor for mitochondrial β-oxidation. L-Carnitine hydrochloride facilitates the transport of long-chain fatty acyl-CoAs into mitochondria for subsequent degradation via β-oxidation, thereby supporting cellular energy metabolism. L-Carnitine hydrochloride also displays antioxidant activity and can mitigate metabolic imbalances associated with numerous inborn errors of metabolism, positioning it as an important agent in metabolic research.

L-Propargylglycine ((S)-Propargylglycine) is an inhibitor of the enzyme.

Mal-Toxophore is a drug-linker complex used in the synthesis of ADCs (Antibody-Drug Conjugates). Its active payload consists of an NAMPT inhibitor.

Antiproliferative agent-63 (compound 4d) is a cyclic analog of cannabidiol that acts as an anticancer agent. It demonstrates favorable activity against breast and colorectal cancer. Moreover, this compound can arrest the cell cycle in the G1 phase and induce apoptosis through the mitochondrial pathway in breast cancer cell lines.

L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.

HDAC-IN-81 (Compound 11g) is an HDAC inhibitor capable of effectively inhibiting HDAC1 with an IC50 value of 4.5 nM. Additionally, it exhibits anticancer activity by inhibiting cell proliferation and can induce cell apoptosis (apoptosis).

Quercetin-d3 hydrate, a deuterated form of Quercetin hydrate, acts as a flavonoid that stimulates recombinant SIRT1 and serves as a PI3K inhibitor. The compound specifically exhibits IC50 values of 2.4 μM, 3.0 μM, and 5.4 μM against PI3Kγ, PI3Kδ, and PI3Kβ, respectively.

Isoproterenol sulfate anhydrous is a useful alkaloid. It is used for biological research.

KAT6A-IN-1 (compound 5) is an inhibitor of KAT6A.

PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.

Pyraoxystrobin, a QoI-type fungicide, exhibits an EC50 of 0.0094 μg/mL against Magnaporthe oryzae (M. oryzae) isolates. It is utilized in the study of rice blast fungus in paddy fields.

BTK-IN-38 (Example 125) is an efficacious inhibitor of BTK. It effectively suppresses the proliferation of DOHH2 and BT474 cells, with IC50 values of 114 nM and 340 nM, respectively.

Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.

DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6), significantly reducing self-administered nicotine doses in both male and female mice.

DYR530 is a ligand for the target protein (protein kinase DYRK1A) of PROTAC.

XH161-180 is an effective and orally active inhibitor of ubiquitin carboxyl-terminal hydrolase 2 (USP2). It reduces the protein levels of cyclin D and ACE2, exhibiting antiproliferative activity. XH161-180 also has potential for research in cancers and viral infections that depend on ACE2.

Antifungalagent 122 (compound 201), a potent and broad-spectrum antifungal agent, prevents the phase shift in fungi and the formation of fungal biofilms. This compound effectively inhibits the enzymatic activity of CYP3A4-M and CYP3A4-T, with IC50 values of 2.11 and 4.53 µM, respectively. Notably, Antifungalagent 122 exhibits no cytotoxicity.

Pyrocatechol sulfate, a phenolic metabolite found in human plasma, is associated with the intake of specific foods such as berries and the state of the gut microbiome. It serves as a potential urinary biomarker for kidney function, dialysis clearance rates, whole grain consumption, and regular coffee intake. Additionally, in conjunction with other phenolic sulfates, pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiac cells.

α-Synucleinmodulator 1 (Compound 7k) acts as a modulator of α-synuclein. In an ACN/PBS (1:1) buffer solution, it exhibits maximum absorption and emission wavelengths at 386 nm and 603 nm, respectively.

SEP-363856 (SEP-856) mesylate is an orally active compound that acts as an agonist for both TAAR1 and 5-HT1A receptors. This compound exhibits antipsychotic activity in the central nervous system and has potential for the study of schizophrenia.

KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.

Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.