T2001

PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.

PNT2001 (LY4181530) is an effective prostate-specific membrane antigen (PSMA) ligand with an IC50 of 3.1 nM. It enhances cellular internalization and, when labeled with 177Lu and 225Ac, is applicable for prostate cancer research.

Diuron is an orally active benzoylurea herbicide against annual, perennial broadleaf weeds, and grass weeds. Diuron inhibits the production of ATP and NADH, thereby impairing plant photosynthesis, and also increases ROS production and promotes DMBA/BBN-induced bladder cancer development.

PF-07899895 (compound 34) is a potent SIK (salt-induced kinase) inhibitor with IC50 values of 1.2/0.9/1.8 nM for SIK1/SIK2/SIK3.

Adamantanine (NSC-145160) is an amino acid transport inhibitor.

AB25583 is a potent inhibitor of the Polθ helicase domain (Polθ-hel). It blocks MMEJ repair, leading to DNA damage accumulation and synthetic lethality in BRCA1/2-deficient cancer cells.

AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.

Enzomenib is a menin protein inhibitor that disrupts the interaction between menin and mixed lineage leukemia fusion proteins, thereby modulating transcriptional programs driven by MEN gene dysregulation and providing a targeted research tool for mechanistic studies and therapeutic exploration in hematological malignancies associated with menin-dependent oncogenic signaling.

Diphenyl(p-tolyl)phosphine is a reagent used in biochemical experiments. Its triarylphosphine structure endows it with both excellent stability and coordination activity, enabling it to form complexes with metal ions. It is often used as a ligand to assist in regulating organic synthesis reactions related to biochemistry.

Melitracen is a tricyclic antidepressant.

7-Bromo-1-heptanol is a biochemical reagent that combines the characteristics of halogenated hydrocarbons and alcohol hydroxyl groups. It can be used as a specific reaction substrate or molecular modification unit in experiments. 7-Bromo-1-heptanol is one of the practical reagents for organic synthesis and biochemical research.

NPT200-11 is an orally bioavailable and brain penetrating inhibitor of accumulation of alpha-synuclein (ASYN) misfolding and aggregation. NPT200-11 can be used in studies about the underlying pathology of synucleinopathies including Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA).

Minzasolmin(DLX-313) is an alpha-synuclein misfolding inhibitor for the study of Parkinson's disease.