T20003

Acridone could induce cell apoptosis, inhibited ABCG2 (ATP-binding cassette sub-family G member 2) protein, and adjusted hormone level.

MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.

Raseglurant (ADX-10059) is a negative allosteric modulator of the mGlu5 receptor that demonstrates efficacy against migraine and significantly reduces haloperidol-induced catalepsy in mice, Raseglurant is widely used in neuropharmacology research to study glutamatergic modulation, motor side effects of antipsychotics, and migraine-related signaling pathways.

(S,R,S)-AHPC-O-CF3 serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2/4-degrader-20.