T1458

Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control.

Biotin-PEG11-amine is a PEG-based linker with biotin labeling which finds application in the synthesis of PROTACs[1].

Biotin-PEG12-acid is a PEG-based PROTAC linker labeled with biotin, designed for synthesis of PROTACs[1].

Biotin-PEG2-acid, a non-cleavable 2-unit PEG ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

Biotin-PEG2-azide, a PEG-based PROTAC linker, can be used in the synthesis of PROTACs.

Biotin-PEG2-C4-alkyne, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Biotin-PEG2-C6-azide is a PEG-based PROTAC linker used in the synthesis of PROTAC.

Biotin-PEG2-Mal is a PEG-based linker for PROTACs that joins two essential ligands necessary for forming PROTAC molecules, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG2-NH-Boc, a PEG-based PROTAC linker labeled with biotin, facilitates its application in PROTAC synthesis [1].

Biotin-PEG2-NHS ester is a PROTAC linker consisting of biotin, PEG and NHS for the synthesis of PROTAC.

Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This heterobiofunctional biotin PEG derivative contains a carboxylic acid group. The hydrophilic PEG spacer arm imparts water solubility to the biotinylated molecule. [PEG Linkers] may be useful in the development of antibody-drug conjugates and drug delivery methods.