Search Result

Search Results for " rdrp "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T9617	RdRP-IN-2		SARS-CoV
	RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. It significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.It also inhibits Feline coronavirus (FIPV) replication.		SARS-CoV
T40267	RdRP-IN-3
	RdRP-IN-3, a potential anti-influenza drug candidate, functions by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).
T79233	RdRP-IN-6		DNA/RNA Synthesis
	RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM. It has potential applications in antiviral and anticancer research [1].		DNA/RNA Synthesis
T62812	RdRP-IN-4
	RdRP-IN-4 (compound 11q) is an arylbenzohydrazide analogue, an orally active inhibitor of influenza A virus RNA-dependent RNA polymerase (RdRp) that directly binds the PB1 subunit of RdRp. RdRP-IN-4 inhibited H1N1 (A/PR/...
T73323	RdRP-IN-5		Influenza Virus
	RdRP-IN-5 (compound 20), a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), has potential application in influenza research [1].		Influenza Virus
T79234	RdRP-IN-7		SARS-CoV
	RdRP-IN-7, a RNA-dependent RNA polymerase (RdRp) inhibitor, demonstrates efficacy against SARS-CoV-2 infection with an inhibitory concentration (IC50) of 8.2 μM and (IC90) of 14.1 μM, alongside a cytotoxic concentration ...		SARS-CoV
T72792	Trans-RdRP-IN-5
	Trans-RdRP-IN-5 is a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), with applications in influenza virus research.
T72896	Cis-RdRP-IN-5
	Cis-RdRP-IN-5 is an effective inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), employed in influenza virus research.
T9618	HeE1-2Tyr		SARS-CoV
	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.		SARS-CoV
T6729	Lomibuvir	VX-222,VCH-222	HCV Protease
	Lomibuvir (VCH-222) (VX-222) is a selective, non-nucleoside allosteric inhibitor of HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC 50 of 5.2 nM. Lomibuvir...		HCV Protease
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T5539	GS-443902		Nucleoside Antimetabolite/Analog , HCV Protease , SARS-CoV , DNA/RNA Synthesis , RSV , Drug Metabolite
	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
T24040	ERDRP-0519	ERDRP0519,ERDRP 0519	Antiviral
	ERDRP-0519 is an orally bioavailable small-molecule inhibitor of the Measles virus (MeV) polymerase. It effectively prevents measles disease in squirrel monkeys (Saimiri sciureus) and exhibits potent inhibition of morbil...		Antiviral
T72051	LabMol-319		Virus Protease
	LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.		Virus Protease
T28762	Setrobuvir	RO-5466731,ANA-598,RG7790,ANA598,RG-7790	HCV Protease , SARS-CoV , DNA/RNA Synthesis
	Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding aff...		HCV Protease , SARS-CoV , DNA/RNA Synthesis
TQ0162	R-1479	4'-Azidocytidine	HCV Protease
	R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.		HCV Protease
T8886	NITD-2		DNA/RNA Synthesis
	NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DENV) is the most prevalent mosquito- borne viral pathogen in hu...		DNA/RNA Synthesis
T10491	Galidesivir	BCX4430,Immucillin-A	Others
	Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and re...		Others
T9103	BVDV-IN-1		DNA/RNA Synthesis
	BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. It directly binds to a hydrophobic pocket of the BVDV RdRp. It has antiviral activity against BVDV resistant to...		DNA/RNA Synthesis
T6833	Favipiravir	T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide	Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
	Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.		Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
T38761	GS-443902 trisodium	GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
	GS-443902 trisodium (GS-441524 triphosphate trisodium), the active triphosphate metabolite of Remdesivir (GS-5734), serves as a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), displaying inhibitory concen...
T71748	RK-0404678
	RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T10491L	Galidesivir hydrochloride	BCX 4430 hydrochloride,Immucillin-A hydrochloride	Others
	Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.		Others
T62160	AS-136A
	AS-136A is an orally active, non-nucleoside inhibitor of measles virus RNA-dependent RNA polymerase (RdRp) that acts against measles virus (IC50: 2 μM).
T83251	7-51A		Influenza Virus
	7-51A is an effective inhibitor of the PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRP), with a dissociation constant (K_D) of 1.64 nM as determined by isothermal titration calorimetry (ITC).		Influenza Virus
T73156	LabMol-301
	LabMol-301, a chemical compound, effectively inhibits NS5 RdRp and NS2B-NS3pro activity with IC50 values of 0.8 μM and 7.4 μM, respectively. Additionally, it exhibits cytoprotective effects, safeguarding against Zika vir...
T80760	XSJ2-46		Influenza Virus
	XSJ2-46, a 5'-amino NI analog, is an antiviral agent possessing anti-Zika virus properties and demonstrates reasonable inhibition of RNA-dependent RNA polymerases (RdRp), with an IC50 of 8.78 μM [1].		Influenza Virus
T63131	ZIKV-IN-1
	ZIKV-IN-1 is a potent inhibitor of zika virus (EC50: 2.8 μM, EC90: 6.8 μM). zIKV-IN-1 has anti-ZIKV effects and low cytotoxicity. zIKV-IN-1 shows high affinity for the RdRp domain of ZIKV.
T81204	SARS-CoV-2-IN-67		SARS-CoV
	SARS-CoV-2-IN-67 (Compound 16), a derivative of vitamin K, exhibits anti-SARS-CoV-2 properties, with an effective concentration (EC50) of 64.8 μM in VeroE6/TMPRSS2 cells, and inhibits SARS-CoV-2 RdRp activity [1].		SARS-CoV
T11352	Galidesivir triphosphate	BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870	Others
	Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA pol...		Others
T63253	AVG-233		DNA/RNA Synthesis , RSV
	AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytia...		DNA/RNA Synthesis , RSV
T63598	DENV-IN-4
	DENV-IN-4 is a potent inhibitor of DENV (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). The antiviral effect was demonstrated by the concentration-dependent reduction of DENV2 expression and the inhibition of RNA-depende...
T63337	CYP2C19-IN-1
	CYP2C19-IN-1 is a potent, non-genotoxic, non-hepatotoxic inhibitor of CYP2C19. CYP2C19-IN-1 inhibits RNA-dependent RNA polymerase (RdRP) (Ki: 6.16 μM) and can be used to study Zika virus (ZIKV) infection.
T63936	GSK5852
	GSK5852 (GSK2485852) is an HCV NS5B RdRp polymerase inhibitor. GSK5852 inhibits NS5B (IC50: 50 nM). GSK5852 exhibits antiviral effects against hepatitis C virus (HCV) with EC50 values of 3.0 nM for GT1a and 1.7 nM for GT...
T41177	Galidesivir dihydrochloride	BCX 4430
	Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arena...
T80729	ZIKV-IN-6
	ZIKV-IN-6 (compound 22) acts as a direct inhibitor of the Zika virus (ZIKV) by binding to its RNA-dependent RNA polymerase (RdRp) and obstructing viral RNA synthesis mediated by the ZIKV NS5 protein. This compound also d...
T32050	HCV-371	HCV 371
	HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ a...
T73253	EIDD-2749	4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU
	EIDD-2749 (4'-Fluorouridine), an orally active RdRp inhibitor, effectively inhibits the replication of RSV and SARS-CoV-2. It also demonstrates activity against HCV and lymphocytic choriomeningitis virus (LCMV), highligh...
T73814	Cis-Lomibuvir
	Cis-Lomibuvir (cis-VX-222), a cis-isomer of Lomibuvir, is a selective non-nucleoside inhibitor of the hepatitis C virus (HCV) NS5B polymerase (RdRp), targeting thumb pocket 2 with a dissociation constant (Kd) of 17 nM. I...
T75303	Suramin
	Suramin is a reversible, competitive inhibitor of protein-tyrosine phosphatases (PTPases) [1], demonstrating potent inhibition against sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM) [2]. It a...
T62469	RSV/IAV-IN-3
	RSV/IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) (EC50: 2.92 μM) and influenza A virus (IAV) (EC50: 1.90 μM). RSV/IAV-IN-3 significantly inhibited luciferase activity in a dose-depend...
T79836	Arbemnifosbuvir		SARS-CoV
	Arbemnifosbuvir, a drug interfering with the nidovirus DdRp-associated nucleotidyltransferase (NiRAN) domain of non-structural protein 12 (nsp12), is utilized in research of SARS-CoVs infections [1].		SARS-CoV

Compounds

Target: DNA/RNA Synthesis

Target: Influenza Virus

Synonym: VX-222,VCH-222

Target: HCV Protease

Simeprevir

T4686

Synonym: TMC435,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

GS-443902

T5539

Synonym:

Target: Nucleoside Antimetabolite/Analog, HCV Protease, SARS-CoV, DNA/RNA Synthesis, RSV, Drug Metabolite

ERDRP-0519

T24040

Synonym: ERDRP0519,ERDRP 0519

Target: Virus Protease

Setrobuvir

T28762

Synonym: RO-5466731,ANA-598,RG7790,ANA598,RG-7790

Target: HCV Protease, SARS-CoV, DNA/RNA Synthesis

R-1479

TQ0162

Synonym: 4'-Azidocytidine

Target: DNA/RNA Synthesis

Galidesivir

T10491

Synonym: BCX4430,Immucillin-A

Target: DNA/RNA Synthesis

Favipiravir

T6833

Synonym: T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide

Target: Others, SARS-CoV, Influenza Virus, DNA/RNA Synthesis

GS-443902 trisodium

T38761

Synonym: GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium

Galidesivir hydrochloride

T10491L

Synonym: BCX 4430 hydrochloride,Immucillin-A hydrochloride

Target: Influenza Virus

Target: Influenza Virus

Galidesivir triphosphate

T11352

Synonym: BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870

Target: DNA/RNA Synthesis, RSV

Galidesivir dihydrochloride

Synonym: 4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU

Cat No.	Product Name	Synonyms	Targets
TN2222	Sotetsuflavone		Others
	Sotetsuflavone, with an IC50 of 0.16 μM, stands as the most active compound in its series, acting as a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase).		Others

Natural Products

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06071	SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His)	SARS-CoV-2	Baculovirus-Insect Cells

TMPJ-01428	SARS-CoV-2 NSP8 Protein (His)	SARS-CoV-2	E. coli
	Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are...
TMPY-06416	SARS-CoV-2 NSP8 Protein	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarka...
TMPY-05749	SARS-CoV-2 NSP8 Protein (Avi)	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarka...
TMPY-02060	Human Enterovirus 71 VP0 Protein (His & GST)	EV71	Baculovirus-Insect Cells
	Human enterovirus 71 genome polyprotein is a member of the picornaviruses polyprotein family. It contains two peptidase C3 domains, one RdRp catalytic domain, one SF3 helicase domain. Genome polyprotein is cleaved into t...

SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His)

TMPY-06071

Species: SARS-CoV-2

Expression System: Baculovirus-Insect Cells

SARS-CoV-2 NSP8 Protein (His)

TMPJ-01428

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP8 Protein

TMPY-06416

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (Avi)

TMPY-05749

Species: SARS-CoV-2

Expression System: E. coli

Human Enterovirus 71 VP0 Protein (His & GST)

TMPY-02060

Species: EV71

Expression System: Baculovirus-Insect Cells

Cat No.	Product Name
L1710	Anti-COVID-19 Compound Library		1160 compounds
	A unique collection of 1160 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents；

Libraries

Anti-COVID-19 Compound Library

L1710

Compounds: 1160