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  • MLK
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Results for "

MLK

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    18
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    2
    TargetMol | PROTAC
  • Recombinant Protein
    2
    TargetMol | Recombinant_Protein
  • Antibody Products
    4
    TargetMol | Antibody_Products
MLK-IN-1
T391021627729-62-7
MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3.
    7-10 days
    Inquiry
    MLK-IN-2
    T869102614255-51-3
    MLK-IN-2 (Compound 9a), with its 3H-imidazole [4,5-b] pyridine structure, serves as a potent Mixed Lineage Kinase 3 (MLK3) inhibitor with an IC50 value of 6 nM. This compound is valuable for research in cancer and neurodegenerative diseases [1].
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    MLKL-IN-2
    T41027899759-16-1In house
    MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
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    TargetMol | Inhibitor Sale
    PROTAC MLKL Degrader-2
    T200218
    PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target protein ligand, E3 ligase ligand Thalidomide, and PROTAC Linker N-Methylpiperazine. The conjugate of the E3 ubiquitin ligase ligand and Linker is Thalidomide-N-Methylpiperazine. This compound exhibits antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.
    • Inquiry Price
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    MLK3-IN-1
    T204487
    MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.
    • Inquiry Price
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    MLKL-IN-1
    T60885
    MLKL-IN-1, a covalent inhibitor of MLKL, has a dissociation constant (Kd) of 50 μM.
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    MLKL-IN-5
    T732792755872-58-1
    MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis.
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    MLKL-IN-6
    T79731
    MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are critical steps in cell necrosis. Additionally, MLKL-IN-6 restrains immune cell death, diminishes adhesion factor expression, exhibits low cytotoxicity, impedes hepatic stellate cell activation, decreases liver fibrosis marker levels, and exerts anti-fibrotic effects [1].
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    PROTAC MLKL Degrader-1
    T79831
    PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, with a degradation maximum (D max) exceeding 90%. The compound incorporates modified cereblon (CRBN) ligands and a lenalidomide-linker within its structure, effectively inhibiting cell death in a TSZ-induced model of necroptosis.
    • Inquiry Price
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    Necrosulfonamide
    (E)-Necrosulfonamide
    T69041360614-48-7
    (E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Binds and inhibits gasdermin D. Inhibits pyroptosis.
    • Inquiry Price
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    TargetMol | Citations Cited
    Cerdulatinib hydrochloride
    PRT2070 hydrochloride, PRT062070 hydrochloride
    T61041369761-01-2
    Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM 6 nM 8 nM 0.5 nM and 32 nM for JAK1 JAK2 JAK3 TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
    • Inquiry Price
    7-10 days
    Size
    QTY
    TargetMol | Inhibitor Sale
    URMC-099
    T60571229582-33-5
    URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19 42 14 150 nM, for MLK1 MLK2 MLK3 DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
    • Inquiry Price
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    gw806742x
    T11520579515-63-2
    GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
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    TargetMol | Inhibitor Sale
    PRT062607 hydrochloride
    PRT062607 (P505-15, BIIB057) HCl, P505-15 Hydrochloride
    T26961370261-97-4
    PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.
    • Inquiry Price
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    LY-364947
    LY 364947, HTS466284
    T2048396129-53-6
    LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
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    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
    (E/Z)-Necrosulfonamide
    T7129432531-71-0
    (E Z)-Necrosulfonamide is a novel inhibitor of MLKL.
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    TargetMol | Inhibitor Sale
    TargetMol | Citations Cited
    AZ7550
    T135641421373-99-0
    AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
    • Inquiry Price
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    IM-54
    IM 54, IM54
    T24160861891-50-1
    IM-54 is a cell-permeable, effective, and selective necrosis inhibitor.
    • Inquiry Price
    6-8 weeks
    Size
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