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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39102 | MLK-IN-1 | ||
MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3. | |||
T41027 | MLKL-IN-2 | MLK | |
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases. | |||
T73279 | MLKL-IN-5 | ||
MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis . | |||
T79831 | PROTAC MLKL Degrader-1 | ||
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as... | |||
T79731 | MLKL-IN-6 | Necroptosis | |
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit... | |||
T60885 | MLKL-IN-1 | ||
MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM. | |||
T6057 | URMC-099 | ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy | |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM). |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01695 | MLKL Protein, Human, Recombinant (His) | Human | Yeast |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat... | |||
TMPH-01694 | MLKL Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat... |