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Search Results for " mlk "

Targets

7

Compounds

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T39102 MLK-IN-1
MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3.
T41027 MLKL-IN-2 MLK
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases.
T73279 MLKL-IN-5
MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis .
T79831 PROTAC MLKL Degrader-1
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as...
T79731 MLKL-IN-6 Necroptosis
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit...
T60885 MLKL-IN-1
MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM.
T6057 URMC-099 ROCK , MLK , VEGFR , SGK , DNA Alkylation , Trk receptor , c-Met/HGFR , LRRK2 , MEK , IGF-1R , Syk , Bcr-Abl , CDK , Src , Aurora Kinase , Autophagy
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM).

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01695 MLKL Protein, Human, Recombinant (His) Human Yeast
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TMPH-01694 MLKL Protein, Human, Recombinant (E. coli, His) Human E. coli
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
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