lrrk2-g2019s — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7155	JH-II-127		LRRK2
	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),		LRRK2
T7729	PF-06454589		LRRK2
	PF-06454589 is a potent inhibitor of LRRK2.		LRRK2
T2022	CZC-54252	CZC54252,CZC 54252	LRRK2
	CZC-54252 is a potent inhibitor of LRRK2.		LRRK2
T5139	CZC-25146 hydrochloride		LRRK2
	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.		LRRK2
T39202	CZC-54252 hydrochloride		LRRK2
	CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human...		LRRK2
T3053	CZC-25146	CHEMBL2397014	LRRK2
	CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.		LRRK2
T39972	EB-42486		LRRK2
	EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.		LRRK2
T2050	PF-06447475		LRRK2
	PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.		LRRK2
T2240	GSK2578215A		Mitophagy , LRRK2 , Autophagy
	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.		Mitophagy , LRRK2 , Autophagy
T2246	LRRK2-IN-1		Apoptosis , LRRK2 , CDK
	LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.		Apoptosis , LRRK2 , CDK
T5184	ERK5-IN-1		ERK
	ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).		ERK
T7196	HG-10-102-01		LRRK2
	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).		LRRK2
T74638	XL01126
	XL01126, a potent degrader of LRRK2, exhibits DC50 values of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. It has the ability to cross the blood-brain barrier, making it a viable degrader probe for Parkinson’s...
T79746	LRRK2-IN-10		LRRK2
	LRRK2-IN-10 (compound 34) is a potent, mutation-selective, brain-penetrant inhibitor targeting G2019S-LRRK2 kinase with IC50 values of 11 nM for G2019S-LRRK2 pS935 and 5.2 nM for G2019S-LRRK2 pS1292. It holds promise for...		LRRK2
T2014	CCG-1423	CCG1423	LRRK2 , Rho , Ras
	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.		LRRK2 , Rho , Ras
T70338	Lu AF58786
	Lu AF58786 is a novel potent and selective inhibitor of LRRK2, inhibiting LRRK2 WT, the overactive variant G2019S, and the resistant mutant A2016T56 at 12 nM, 19 nM and 93 nM, respectively.
T73846	PF-06456384 trihydrochloride
	PF-06447475 trihydrochloride is a potent, selective LRRK2 kinase inhibitor that demonstrates excellent brain penetration, exhibiting IC50 values of 3 nM for wild-type LRRK2 and 11 nM for G2019S LRRK2 variants. It holds p...