Search Result

Search Results for " huvec "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9979	VEGFR-2-IN-29		VEGFR
	VEGFR-2-IN-29 is a VEGFR2 inhibitor.		VEGFR
T11520	GW806742X		MLK , VEGFR
	GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.		MLK , VEGFR
T4435	E7820	ER68203-00	Integrin
	E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).		Integrin
T4425	JK-P3		VEGFR
	JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format...		VEGFR
T7611	ODM-203		VEGFR , FGFR
	ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity		VEGFR , FGFR
T22436	Takeda-6d		VEGFR
	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.		VEGFR
T0692	Allopurinol	Zyloric,Zyloprim,Lopurin	ROS , Xanthine Oxidase
	Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.		ROS , Xanthine Oxidase
T6182	Tirofiban	L700462,Aggrastat,MK383	Integrin
	Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.		Integrin
T6376	Allopurinol Sodium	Allopurinol sodium salt,Sodium allopurinol	ROS
	Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.		ROS
T2537	Tirofiban hydrochloride monohydrate	Tirofiban Hydrochloride,MK-383 Hydrochloride	ATPase , Integrin
	Tirofiban hydrochloride monohydrate (MK-383 Hydrochloride) is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.		ATPase , Integrin
T11076	Dooku1		Others
	Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod...		Others
T0005	Aspirin	Acetylsalicylate,Acetylsalicylic Acid,ASA	Mitophagy , Virus Protease , COX , Autophagy
	Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel...		Mitophagy , Virus Protease , COX , Autophagy
T2500	Cediranib	AZD2171,NSC-732208	VEGFR , FLT , PDGFR , c-Kit , Autophagy
	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...		VEGFR , FLT , PDGFR , c-Kit , Autophagy
T10680	Carebastine		Histamine Receptor
	Carebastine, the active metabolite of Ebastine, is an antagonist of the histamine H1 receptor.		Histamine Receptor
T67836	AT-533		HSP , HSV
	AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, i...		HSP , HSV
T79364	Antiangiogenic agent 4		Akt
	Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].		Akt
T34492	Salinazid	Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1	Others
	Salinazid (Salicylaldehyde isonicotinoyl hydrazone) is a potent Cu(II) ionophore which preferentially kills HepG2 cells over HUVEC cells, and is superior to clioquinol.		Others
T72449	Tubulin inhibitor 31
	Tubulin Inhibitor 31 is a potent compound with an inhibitory concentration (IC 50) of 4 µM, demonstrating significant anti-proliferative activity and the ability to inhibit HUVEC migration.
T27622	IPS-05002
	IPS-05002 is an integrin a5β1 antagonist. IPS-05002 inhibited VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration in a dose-dependent manner. IPS-05002 is a potent inhibit...
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 is a potent inhibitor of human umbilical vein endothelial cells (HUVEC), effectively blocking HUVEC migration and chemotactic motilities. Additionally, it suppresses the gene expression of Src, cdc...
T79702	Nrf2 activator-9
	Nrf2 activator-9 (compound D-36) is an agent that mitigates oxidative stress by inhibiting the apoptosis of HUVEC cells induced by oxidized low-density lipoprotein (oxLDL) and high glucose (HG). It also protects vascular...
T41145	TASP 0277308
	TASP 0277308 is a potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM). TASP 0277308 inhibits S1P-induced chemotaxis (IC50 = 1.1-1.6 nM), HUVEC cell proliferation (IC50 = 3-3.6 nM) an...
T80872	VEGFR-2-IN-37		VEGFR
	VEGFR-2-IN-37 (compound 12), a VEGFR-2 inhibitor, exhibits an inhibition rate of approximately 56.9 μM at a concentration of 200 μM. It is also identified as a potential inhibitor of human umbilical vein endothelial cell...		VEGFR
T62267	18-Deoxyherboxidiene
	18-Deoxyherboxidiene (RQN-18690A) is a potent inhibitor of angiogenesis. 18-Deoxyherboxidiene selectively acts on SF3b, a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidi...
T74627	Angiogenesis inhibitor 3
	Angiogenesis Inhibitor 3 (Compound 8) is a potent substance that effectively inhibits the growth of HUVEC and HCT-15 cells, demonstrating IC50 values of 1.00 and 0.71 μM, respectively. It not only induces apoptosis in th...
T76052	ELA-32(human) TFA
	ELA-32(human) TFA is a potent apelin receptor agonist with high affinity, demonstrating an IC50 of 0.27 nM and a Kd of 0.51 nM. This compound does not bind to GPR15 or GPR25. It activates the PI3K/AKT signaling pathway, ...
T79560	22-(4′-py)-JA	22-(4′-Pyridinecarbonyl) jorunnamycin A	Akt
	22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumo...		Akt
T36138	BMP-22
	BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid...
T82402	Fibulostatin 6.2
	Fibulostatin 6.2, an anti-angiogenic peptide, inhibits the migration of human umbilical vein endothelial cells in vitro [1].
TP2097	ELA-32(human)	ELA-32 (human)
	Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein ...
T78548	3-Hydroxyxanthone	3-Hydroxy-xanthen-9-one	Integrin
	3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein endothelial cells (HUVECs) and suppresses TNF-alpha-induced IC...		Integrin

Compounds

Synonym: Zyloric,Zyloprim,Lopurin

Target: ROS, Xanthine Oxidase

Tirofiban

T6182

Synonym: L700462,Aggrastat,MK383

Target: Integrin

Allopurinol Sodium

T6376

Synonym: Allopurinol sodium salt,Sodium allopurinol

Target: ROS

Tirofiban hydrochloride monohydrate

T2537

Synonym: Tirofiban Hydrochloride,MK-383 Hydrochloride

Target: ATPase, Integrin

Synonym: Acetylsalicylate,Acetylsalicylic Acid,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Cediranib

T2500

Synonym: AZD2171,NSC-732208

Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy

Carebastine

T10680

Synonym:

Target: Histamine Receptor

Antiangiogenic agent 4

Synonym: Nilazid,Salicylaldehyde isonicotinoyl hydrazone,Salizid,Salizide,Nupasal,SIH1

Antiangiogenic agent 3

Angiogenesis inhibitor 3

Synonym: 22-(4′-Pyridinecarbonyl) jorunnamycin A

Synonym: ELA-32 (human)

Target:

3-Hydroxyxanthone

T78548

Synonym: 3-Hydroxy-xanthen-9-one

Target: Integrin

Cat No.	Product Name	Synonyms	Targets
TN1112	Morellic acid		Others
	Morellic acid has anti-cancer activity, it strongly inhibited the migration of HUVEC at a low concentration of 0.5 μM in HUVEC cell migration assay in vitro. Morellic acid also has antiangiogenic activity.		Others
T3982	Vulpinic Acid	Vulpic acid,Pulvinic acid methyl ester	Others
	Vulpinic Acid (Pulvinic acid methyl ester) is a lichen metabolite with anti-inflammatory, antibacteria, properties, plant growth inhibitor.		Others
T2P2870	Damascenone	trans-damascenone,Beta-Damascenone	Others , NF-κB , Endogenous Metabolite
	Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.		Others , NF-κB , Endogenous Metabolite
T3402	20(S)-Ginsenoside Rg3	20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3	EGFR , Beta Amyloid , Potassium Channel , NF-κB , COX , Sodium Channel , Endogenous Metabolite
	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial c...
T6S1784	Brazilin	Natural Red 24,Braziletto,Brasilin,Superbresiline	Apoptosis , Others , AMPK , Autophagy
	1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign...		Apoptosis , Others , AMPK , Autophagy
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T5768	Bruceine B		TNF , Parasite
	Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated ...		TNF , Parasite
TN3706	Coronarin A
	Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the gr...
TN1988	Nephthenol		Others
	Nephthenol shows antiproliferative activity against the cell lines HUVEC and K-562 and for cytotoxicity against the cell line HeLa.		Others
TN5351	Cycloshizukaol A
	Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity...
TN5100	Taspine		ERK , EGFR , BCL , VEGFR , MAPK , Akt
	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful an...		ERK , EGFR , BCL , VEGFR , MAPK , Akt
TN5011	Shizukaol B		ERK , IL Receptor , p38 MAPK , TNF , NOS , NF-κB , COX , HIV Protease , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
	Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production...

Natural Products

Synonym: Vulpic acid,Pulvinic acid methyl ester

Target: Others

Damascenone

T2P2870

Synonym: trans-damascenone,Beta-Damascenone

Target: Others, NF-κB, Endogenous Metabolite

20(S)-Ginsenoside Rg3

T3402

Synonym: 20(S)-Ginsenoside-Rg3,Rg3,20S-Ginsenoside Rg3,Ginsenoside Rg3,S-Ginsenoside Rg3

Target: EGFR, Beta Amyloid, Potassium Channel, NF-κB, COX, Sodium Channel, Endogenous Metabolite

Brazilin

T6S1784

Synonym: Natural Red 24,Braziletto,Brasilin,Superbresiline

Target: Apoptosis, Others, AMPK, Autophagy

Calycosin

T3923

Synonym: Cyclosin,3'-Hydroxyformononetin

Target: Apoptosis, Tyrosinase

Sauchinone

T6S1572

Synonym:

Target: ERK, p38 MAPK, NF-κB

bruceine B

T5768

Synonym:

Target: TNF, Parasite

Target: ERK, EGFR, BCL, VEGFR, MAPK, Akt

Shizukaol B

TN5011

Synonym:

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, HIV Protease, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00293	Nectin-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293
	Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Nectin-2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymp...
TMPY-02246	HB-EGF Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolyticall...

Nectin-2 Protein, Human, Recombinant (His & Avi)

TMPK-00293

Species: Human

Expression System: HEK293

HB-EGF Protein, Human, Recombinant

TMPY-02246

Species: Human

Expression System: Baculovirus-Insect Cells