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Results for "

DYRK

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    42
    TargetMol | Activity
  • Peptide Products
    1
    TargetMol | inventory
  • Natural Products
    2
    TargetMol | natural
  • Recombinant Protein
    1
    TargetMol | composition
AZ-Dyrk1B-33
T143641679330-37-0
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
  • $39
In Stock
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TargetMol | Inhibitor Sale
GNF4877
T114472041073-22-5In house
GNF4877 is a potent inhibitor of DYRK1A and GSK3β (IC50s: 6 nM and 16 nM, respectively), resulting in the blockade of nuclear export of nuclear factor of activated T-cells (NFATc) and increased β-cell proliferation.
  • $127
In Stock
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TargetMol | Inhibitor Hot
EHT 1610
T152041425945-60-3In house
EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively. EHT 1610 has an inhibitory effect on leukemia, regulating cell cycle and inducing cell apoptosis.
  • $147
In Stock
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QTY
CK2/ERK8-IN-1
T108271085822-09-8In house
CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25 µM).
  • $30
In Stock
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QTY
TargetMol | Inhibitor Sale
YK-2-69
T695642619846-89-6In house
YK-2-69 is a highly selective DYRK2 inhibitor with anti-prostate cancer effects.
  • $293 TargetMol
In Stock
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Harmine
T1711442-51-3
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
  • $30
In Stock
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QTY
TargetMol | Citations Cited
ProINDY
T23186719277-30-2
ProINDY (Pro-indy) is a potent DYRK inhibitor that activates NFAT for the study of Down syndrome.
  • $92
In Stock
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ML 315
T367071440251-53-5
ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.
  • $44
In Stock
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QTY
AnnH31
T26632241809-12-1
AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the involvement of DYRK1A in cellular phosphorylation.
  • $213
In Stock
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ARN25068
T613602649882-80-2In house
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1].
  • $115
In Stock
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CLK1-IN-3
T720392922550-28-3In house
Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly effective inhibition of Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 is effective in inducing autophagy in vitro and can be used for prevention and human treatment of acute liver injury (ALI).
  • $106
In Stock
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HTH-01-091
T241522000209-42-5In house
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM) that also inhibits PIM1 2 3, RIPK2, DYRK3, smMLCK, and CLK2. It can be used to study breast cancer.
  • $296
In Stock
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DYRKs-IN-2
T111331386980-04-6
DYRKs-IN-2 has antitumor activity. DYRKs-IN-2 is a potent DYRKs inhibitor with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively.
  • $2,120
8-10 weeks
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DYRKs-IN-1
T111321387090-01-8
DYRKs-IN-1 has antitumor activity. DYRKs-IN-1 is a potent DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) inhibitor with IC50s of 9 nM and 5 nM for DYRK1B and DYRK1A, respectively.
  • $2,870
10-14 weeks
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AZ191
T62571594092-37-1
AZ191(IC50 of 17 nM) is an effective and specific DYRK1B inhibitor. The specificity of AZ191 for DYRK1B is about 5- and 110-fold greater over DYRK1A and DYRK2, respectively.
  • $39
In Stock
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TargetMol | Inhibitor Sale
TargetMol | Citations Cited
LDN-192960
TQ0111184582-62-5
LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).
  • $133
In Stock
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TargetMol | Inhibitor Sale
ID-8
T2431147591-46-6
ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.
  • $34
In Stock
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TargetMol | Inhibitor Sale
CLK-IN-T3
T149802109805-56-1
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.
  • $32
In Stock
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GNF2133
T401872561414-56-8
GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.
  • $132
In Stock
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TargetMol | Inhibitor Sale
7BIO
T22012916440-85-2
7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.
  • $38
In Stock
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TargetMol | Inhibitor Sale
INDY
T155791169755-45-6
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
  • $33
In Stock
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TargetMol | Inhibitor Sale
ML167
T26701285702-20-6
ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
  • $29
In Stock
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TargetMol | Inhibitor Sale
GSK-626616
T154221025821-33-3
GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.
  • $44
In Stock
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TargetMol | Inhibitor Sale
Protein kinase inhibitors 1
T46361365986-44-2
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
  • Inquiry Price
1-2 weeks
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Harmine hydrochloride
T2811343-27-1
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.
  • $41
In Stock
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TargetMol | Inhibitor Sale
MBM-55
T119602083622-09-5
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
  • $187
In Stock
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Dyrk1A-IN-8
T87614101578-13-6
  • Inquiry Price
10-14 weeks
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Dyrk1A-IN-4
T608672091883-59-7
Dyrk1A-IN-4 (compound 48) is a potent and orally active dual inhibitor of DYRK1A (IC50 = 2 nM) and DYRK2 (IC50 = 6 nM) with anticancer effects [1].
  • $1,520
10-14 weeks
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Dyrk1A/B-IN-1
T62043
Dyrk1A B-IN-1 (compound 3n) is a potent, selective, and cell-permeable inhibitor of DYRK1A and DYRK1B, with Kis of 67.8 nM and 237.9 nM, and IC 50 s of 1.1 μM and 0.8 μM, respectively.
  • $1,520
10-14 weeks
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Dyrk1A/α-synuclein-IN-2
T62226
Dyrk1A α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation with an IC50 of 7.8 μM for α-synuclein. It exhibits high predictive CNS permeability and has a neuroprotective effect.
  • $1,520
10-14 weeks
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Dyrk1A-IN-3
T608242493976-27-3
Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) with a high binding affinity (IC50 of 76 nM). Dyrk1A-IN-3 can be used in neurodegenerative disorders research, such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease [1].
  • $1,520
6-8 weeks
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DYRK1-IN-1
T603342814486-79-6
DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor that inhibits DYRK1A phosphorylation activity with an IC50 value of 220 nM. It exhibits good permeability and cellular activity without P-glycoprotein liability, making it suitable for research on central nervous system penetrant DYRK1A chemical probes [1].
  • $1,450
10-14 weeks
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Dyrk1A-IN-1
T62414
Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, tau aggregation, and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.
  • $1,520
10-14 weeks
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Dyrk1A-IN-5
T617391685235-41-9
Dyrk1A-IN-5 (compound 5j) is a highly potent and selective DYRK1A inhibitor with an IC50 of 6 nM, reducing the phosphorylation of Thr434 in SF3B1 dose-dependently (IC50 = 0.5 μM) and inhibiting tau phosphorylation at Thr212 (IC50 = 2.1 μM), making it valuable for Down syndrome research [1].
  • $1,070
6-8 weeks
Size
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Dyrk1A-IN-2
T63440
Dyrk1A-IN-2 is a DYRK1A inhibitor (EC50: 37 nM). dyrk1A-IN-2 exhibits efficient promotion of human β-cell replication, as well as low cytotoxicity.
  • $1,520
10-14 weeks
Size
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Dyrk1A/α-synuclein-IN-1
T62096
Dyrk1A α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM), characterized by CNS permeability and neuroprotective activity.
  • $1,520
10-14 weeks
Size
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DYRKs-IN-1 hydrochloride
T722421386980-55-7
DYRKs-IN-1 hydrochloride is a potent inhibitor of Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs), with IC50 values of 5 nM for DYRK1A and 8 nM for DYRK1B, and exhibits antitumor activity.
  • $2,450
10-14 weeks
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DYRKi
T272261640364-04-0
DYRKi is a nontoxic, DYRK1-selective inhibitor.
  • $1,520
6-8 weeks
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KuWal151
T36689
Potent and selective CLK inhibitor (IC50 values are 28, 88 and 510 nM for CLK4, 1 and 2, respectively). Exhibits no significant activity at CLK3, DYRK, CDK or GSK3 at a concentration of 10 μM. Inhibits growth of a range of cancer cell lines in vitro at subnanomolar concentrations. Walter et al (2018) Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype. PLoS One 13 e0196761 PMID:29723265
  • $206
Backorder
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Woodtide
T76409634592-23-7
Woodtide, a substrate for the DYRK (DYRK) family of kinases, is designed based on the sequence surrounding the DYRK phosphorylation site in FKHR [1] [2].
  • Inquiry Price
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Leucettinib-92
T795622732859-57-1
Leucettinib-92 (compound 92) is a kinase inhibitor selective for the DYRK CLK families, with IC50 values of 147 nM for CLK1, 39 nM for CLK2, 5.2 nM for CLK4, 0.8 μM for CLK3, 124 nM for DYRK1A, 204 nM for DYRK1B, 0.16 μM for DYRK2, 1.0 μM for DYRK3, 0.52 μM for DYRK4, and 2.78 μM for GSK3 [1].
  • Inquiry Price
8-10 weeks
Size
QTY
ML 315 hydrochloride
T847122172559-91-8
ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].
  • Inquiry Price
8-10 weeks
Size
QTY