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Demeclocycline hydrochloride (Declomycin) is a TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.

Demeclocycline calcium is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.

Demeclocycline (Declostatin) is a tetracycline antibiotic produced by a strain of Streptomyces aureofaciens.Demeclocycline has antimicrobial activity and inhibits the action of vasopressin on the renal tubules, leading to diuresis. Demeclocycline can be used to induce diuresis and acute renal failure.