4-aminopyridine

4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.

3-Hydroxy-4-aminopyridine is a natural product for research related to life sciences. The catalog number is T66009 and the CAS number is 52334-53-9.

4-Aminopyridine (Standard) is the standard substance of 4-Aminopyridine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 4-Aminopyridine (Dalfampridine) is a nonselective potassium (K+) channel blocker that binds to the cytoplasmic side of the cell membrane.

Heterocyclic compound-pyridine, intermediate and building block-nucleophile

Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes.

GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion.

2,4-Dichloro-3-nitro-4-(N-ethoxycarbonyl)aminopyridine is a useful organic compound for research related to life sciences. The catalog number is TNU0895 and the CAS number is 947146-17-0.

Methyl 2-aminoisonicotinate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Methyl 3-aminopyridine-4-carboxylate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.