20 (tert butoxy) 20 oxoicosanoic acid

20-(tert-Butoxy)-20-oxoicosanoic acid is an alkyl-chain-based, non-cleavable PROTAC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Squalane is a lipid found in some fish oils (especially shark liver oil) and some vegetable oils. It has anticancer and antioxidant properties and is used as a skin moisturizer and emollient.

HO-PEG20-OH, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based linker compound used in the synthesis of PROTACs, enabling efficient conjugation and acting as a bridge between the target protein and the E3 ligase, thereby facilitating targeted protein degradation[1].

Amino-PEG20-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands necessary for assembling PROTAC molecules. This compound enables selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG20-Boc, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules, enabling selective protein degradation by leveraging the [ubiquitin-proteasome system] within cells.

Azido-PEG20-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Boc-NH-PEG20-CH2CH2COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Cbz-N-amido-PEG20-acid is a PEG-based linker for PROTACs [proteolysis-targeting chimeras] that connects two critical ligands essential for the formation of PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1 2 ~20 hours)[1][2].

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, useful in the synthesis of PROTACs, as per reference [1].

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. Incorporating a Pomalidomide-derived cereblon ligand that selectively binds to the E3 ligase cereblon and a 2-unit PEG linker, it provides stability and flexibility to the conjugate.

Fmoc-N-amido-PEG20-acid is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1].

Hydroxy-PEG20-Boc is a PEG-based linker for PROTACs, joining two essential ligands vital for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG20-Tos is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. [PEG20-Tos]

S-acetyl-PEG20-alcohol is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

SNIPER(ABL)-013, a compound that links GNF5 (ABL inhibitor) with Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 20 μM[1].

Tos-PEG20-Tos is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(S,R,S)-AHPC-O-CF3 serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2 4-degrader-20.

(S,R,S)-AHPC-O-CF3-CO-cyclohexane serves as an E3 Ligase Ligand-Linker Conjugate and is utilized in the synthesis of PROTAC SMARCA2 4-degrader-20.

PROTAC SMARCA2 degrader-20 (Compound I-40) is a potent degrader of PROTAC SMARCA2, showing potential for cancer research applications.

PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.

QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.

m-PEG20-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.