20(tertbutoxy)20oxoicosanoic acid

20-(tert-Butoxy)-20-oxoicosanoic acid is an alkyl-chain-based, non-cleavable PROTAC linker utilized in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-N-amido-PEG20-acid is a polyethylene glycol (PEG)-based PROTAC linker used in the synthesis of PROTACs[1].

Boc-NH-PEG20-CH2CH2COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

(S,R,S)-AHPC-O-CF3 serves as a ligand for E3 ubiquitinase and is utilized in the synthesis of PROTAC SMARCA2 4-degrader-20.

(S,R,S)-AHPC-O-CF3-CO-cyclohexane serves as an E3 Ligase Ligand-Linker Conjugate and is utilized in the synthesis of PROTAC SMARCA2 4-degrader-20.

PROTAC BRD4 Degrader-20 (compound 195) is a bifunctional degrader of BRD4 [1].

Amino-PEG20-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands necessary for assembling PROTAC molecules. This compound enables selective protein degradation via the ubiquitin-proteasome system within cells.

Amino-PEG20-Boc, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules, enabling selective protein degradation by leveraging the [ubiquitin-proteasome system] within cells.

Azido-PEG20-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

VH 101, a thiol (compound 20), serves as a VHL ligand essential for PROTAC synthesis [1].

PROTAC SMARCA2 degrader-20 (Compound I-40) is a potent degrader of PROTAC SMARCA2, showing potential for cancer research applications.

PROTAC K-Ras degrader-2 (compound 48) is a broad-spectrum KRAS mutant PROTAC degrader that demonstrates an IC50 of ≤200 nM for KRAS G12V RAF1. Additionally, PROTAC K-Ras degrader-2 achieves a DC50 of ≤200 nM in degrading SW620 KRAS G12D and inhibits the growth of SW620 3D cells with an IC50 of ≤20 nM.

Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, useful in the synthesis of PROTACs, as per reference [1].

S-acetyl-PEG20-alcohol is a PEG-based linker for PROTACs, joining two essential ligands and facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. Incorporating a Pomalidomide-derived cereblon ligand that selectively binds to the E3 ligase cereblon and a 2-unit PEG linker, it provides stability and flexibility to the conjugate.

PROTAC SMARCA2 4-degrader-20 (Compound I-405) is a PROTAC degrader targeting the catalytic subunit SMARCA2 in the SWI SNF complex. It degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM. Additionally, it degrades SMARCA4 in MV411 with a DC50 ranging between 100 to 500 nM.

SMARCA2 degrader-20, a potent PROTAC SMARCA2 degrader, exhibits a DC50 value of less than 100 nM in A549 cells.

C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a concentration of 20 µM. This compound exhibits cytotoxicity to a range of cancer cells, including 786-O, 4T1, PANC-1, HGC-27, and MCF-7, with IC50 values of 34.07 µM, 5.08 µM, 31.53 µM, 6.11 µM, and 21.65 µM, respectively. Additionally, at 20 µM, C-02 diminishes both the extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) in 4T1 cells, suggesting a suppression of glycolysis and mitochondrial damage. In vivo studies reveal that at a dosage of 50 mg/kg, C-02 not only reduces tumor volume but also promotes intratumoral cytokine accumulation and triggers pyroptosis in a 4T1 murine mammary carcinoma model.

QZ2135 (compound 20) is a PROTAC degrader that specifically targets RET and exhibits antitumor activity in vivo within a Ba F3-KIF5B-RET-G810C xenograft mouse model. The compound demonstrates degradation activity with DC50 values of 4.7 nM (WT), 17.2 nM (V804M), and 73.8 nM (G810C) when targeting KIF5B-RET. QZ2135 is composed of the target protein ligand (red part) RETligand-3, the E3 ligase ligand (blue part) Lenalidomide-F, and the PROTAC Linker (black part) 7-Iodohept-1-yne, wherein the target protein ligand combined with the linker forms the conjugate RETLigand-Linker Conjugate-1.

m-PEG20-alcohol is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PEG20-Tos is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. [PEG20-Tos]

Tos-PEG20-Tos is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hydroxy-PEG20-Boc is a PEG-based linker for PROTACs, joining two essential ligands vital for forming PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1 2 ~20 hours)[1][2].