2-fluoroadenosine

2-Fluoroadenosine is a potent inhibitor of lymphocyte-mediated cytolysis.

2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium, an ATP analog, exhibits robust mixed-type inhibition of [poly(AU)] synthesis.

Nucleoside Phosphates; Nucleoside Derivateives - 2'-Modified nucleosides; Fluoro-modified nucleosides

2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors expressing E. coli PNP. 2'-Fluoro-2'-Deoxyadenosine can be used to synthesize 2'-deoxy-2'-fluoromodified oligonucleotides that can hybridize to RNA.

2'-Deoxy-2'-fluoroadenosine 5'-monophosphate (triethylammonium) is a purine nucleoside analog with significant antitumor properties, especially against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and induction of apoptosis, among other mechanisms [1].

2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate is a fluorinated analog of ATP, the pivotal energy substrate for cellular metabolism, and acts as an inhibitor of E. coli RNA polymerase (Ki = 200 µM).

2-Amino-3'-deoxy-3'-fluoroadenosine is a Nucleoside Derivative - Fluoro-modified nucleoside; 3'-Modified nucleoside.

8-Chloro-2'-deoxy-2'-fluoroadenosine is a Nucleoside Derivative - Halo-nucleoside, 8-Modified purine nucleoside, Fluoro-modified nucleoside.