Rhodiocyanoside A (Multifidin) is a flavonoid that can be extracted from Rhodiola, showing inhibitory activity against histamine release from peritoneal exudate cells sensitized with anti-2,4-dinitrophenyl IgE in rats.
Crenulatin, a natural gallotannin, has a bi-directional effect on apoptosis in mouse cerebral microvascular endothelial cells, acting through the regulation of Fas Bcl-2 expression and caspase-3 activity.
Rhodiolin, a natural product from Rhodiola rosea, blocks glycolysis of glucose 6-phosphate isomerase (GPI) in human papillary thyroid cancer (PTC), inhibits phosphorylation of the PI3K AKT mTOR signaling pathway and induces apoptosis of PTC cells.