(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.

Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.

Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in a concentration-dependent manner and has been used in studies of fungal infections and prostate cancer.

Lotusine, a pure alkaloid extracted from the Nelumbo nucifera Gaertn., affects action potentials in the myocardium and slow inward current in cardiac Purkinje fibers.

O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.

Dehydronuciferine, isolated from the leaves of Nelumbo nucifera Gaertn, exhibits acetylcholinesterase inhibition with an IC50 of 25 µg/mL.

1,2-Dimethylnaphthalene is a specific dimethylnaphthalene isomer carrying methyl substituents at the 1 and 2 positions on the naphthalene ring system, and this polycyclic aromatic hydrocarbon has been reported as a natural constituent in several plant species including Phaseolus vulgaris, Nelumbo lutea, and Magnolia liliiflora.

2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.

(+)-Armepavine is an active compound from Nelumbo nucifera that exhibits anti-inflammatory effects on human peripheral blood mononuclear cells, immunosuppressive effects on T lymphocytes, and protective activity in lupus nephritic mice, in part by inhibiting TNF-α-induced MAPK and NF-κB signaling pathways.

N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa

N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition activities, with the IC50 value of 1

N-Nornuciferine is an aporphine alkaloid derived from lotus leaf that strongly inhibits CYP2D6 with an IC50 of 3.76 μM and Ki of 2.34 μM, and pharmacokinetic studies show rapid absorption into blood with mean Cmax values of 1.71 μg/mL at 0.9 h and 0.57 μg/mL at 1.65 h after administration. Following intravenous dosing at 10 mg/kg, N-Nornuciferine exhibits a wide volume of distribution of 9.48–15.17 L/kg and slow elimination half-lives of 2.09–3.84 h. the oral bioavailability of N-Nornuciferine is estimated at 58.13–79.91%. At 20 mg/kg i.v. dosing, N-Nornuciferine also rapidly crosses the blood–brain barrier, achieving unbound Cmax values of 0.32 μg/mL and 0.16 μg/mL at approximately 0.89–1.22 h.