isotopes

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]. [1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848.[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

SADDNIKTPAE(Arg-13C6,15N4)LLGPLPPSADDNLKT (TFA) is an isotopically labeled version of SADDNIKTPAE-LLGPLPPSADDNLKT (TFA), incorporating 13C and 15N isotopes, and presented as a trifluoroacetate salt.

Angiotensin I-13C6,15N (human, mouse, rat) TFA is a labeled version of Angiotensin I, using isotopes 13C and 15N, specifically targeted for human, mouse, and rat studies. This compound serves as a precursor to angiotensin II, which is formed through the cleavage by angiotensin-converting enzyme (ACE).

L-Lysine-13C6-15N2 Hydrochloride is L-Lysine hydrochloride labeled with 13C and 15N isotopes. L-Lysine hydrochloride is an essential amino acid for humans and a common food additive. It stimulates the secretion of pepsin and gastric acid, enhances gastric juice secretion, and promotes growth and development in children.

2-Bromonaphthalene-d7 is a deuterium-labeled version of 2-Bromonaphthalene. Compounds labeled with stable or radioactive isotopes are useful in metabolic analysis, allowing for precise tracking and quantification of individual atoms movements.

4-Acetyl-N-methylaniline-13C,d3 (1-(4-(Methylamino)phenyl)ethanone-13C,d3) is an isotopically labeled version of 4-Acetyl-N-methylaniline, featuring both 13C and tritium (d3) markers. Compounds marked with stable or radioactive isotopes are utilized in metabolic analysis to precisely trace and quantify the movement of individual atoms.