Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.

Cat. No.	Product name	CAS No.	Purity
T5S0754	Isoquercetin	482-35-9	98%
T5S0754	1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercitrin may be as a potential therapeu...
T6868	KYA1797K	1956356-56-1	98%
T6868	KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
TL0007	Bisdemethoxycurcumin	24939-16-0	98%
TL0007	Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy...
T3S0153	Xanthatin	26791-73-1	98%
T3S0153	1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSC...
T4043	ETC-159	1638250-96-0	98%
T4043	ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
T4011	NCB-0846	1792999-26-8	98%
T4011	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T2003	ISX-9	832115-62-5	98%
T2003	ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.
TL0008	Gigantol	67884-30-4	98%
TL0008	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-cat...
T2413	FH535	108409-83-2	98%
T2413	FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T9642	ZW4864 free base	2632259-92-6	98%
T9642	ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base)...
T3261	NVP-TNKS656	1419949-20-4	98%
T3261	NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor.
T9556	TNIK-IN-3	2754265-25-1	98%
T9556	TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC 50 of 0.026 μM. TNIK-IN-3 could also...
T41094	Wnt/β-catenin agonist 2	943820-93-7	98%
T41094	Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related t...
T11571	HLY78	854847-61-3	98%
T11571	HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signa...
T3062	WIKI4	838818-26-1	98%
T3062	WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T1807	JW 55	664993-53-7	98%
T1807	JW 55 is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2).
T5S1058	Triptonide	38647-11-9	98%
T5S1058	1. Triptonide is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammator...
T4S1943	Kirenol	52659-56-0	98%
T4S1943	1. Kirenol has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol ...
T5729	L-quebrachitol	642-38-6	98%
T5729	L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin ...
T15677	KY1220	292168-79-7	98%
T15677	KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.