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Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2244 ESI-09 263707-16-0 98.48%
ESI-09
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
T38960 QL-X-138 1469988-63-3 98.41%
QL-X-138
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, ...
T63143 DENV-IN-5 2375781-06-7 98.39%
DENV-IN-5
Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
T36433 A2ti-2 482646-13-9 98.31%
A2ti-2
A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity...
T1717 Alpha-Mangostin 6147-11-1 98.12%
alpha-Mangostin
alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T8371 ML188 1417700-13-0 98.04%
ML188
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
TN1202 (-)-α-Pinene 7785-26-4 98.02%
(-)-α-Pinene
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, actin...
T8071 L-Lysine hydrochloride 657-27-2 98%
L-Lysine hydrochloride
L-Lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, reducing diabetes-related illnesses, increasing cal...
T5779 MOSLOFLAVONE 740-33-0 98%
MOSLOFLAVONE
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T6S0095 Genkwanin 437-64-9 98%
Genkwanin
1. Genkwanin (Apigenin 7-methyl ether) exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transp...
T5S1805 5,7-Dihydroxychromone 31721-94-5 98%
5,7-Dihydroxychromone
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. ...
T7366 NGI-1 790702-57-7 98%
NGI-1
NGI-1 (ML414) is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.
T3S1852 Cephaeline hydrochloride 3738-70-3 97.81%
Cephaeline hydrochloride
Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.
T6327 Tubacin 537049-40-4 97.62%
Tubacin
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
T73097 SID-852843 909859-19-4 97.19%
SID-852843
SID-852843 is a WNV NS2B-NS3 protease inhibitor with an IC50 value of 0.105 μM for WNV NS2B-NS3 protease.SID-852843 can be used for the study of viral infections...
T2732 (-)-Epicatechin gallate 1257-08-5 96.65%
(-)-Epicatechin gallate
(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins...
T8903 Retro-2 1201652-50-7 96.08%
Retro-2
Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retro...
T16913 Sotirimod 227318-75-4 95.87%
Sotirimod
Sotirimod(R850) is a novel immunomodulator with antitumor and antiviral activity for the study of actinic keratoses.
T5666 Dipotassium glycyrrhizinate 68797-35-3 89.63%
Dipotassium glycyrrhizinate
Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
T0005 Aspirin 50-78-2 100%
Aspirin
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
ESI-09
T2244
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
QL-X-138
T38960
QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, ...
DENV-IN-5
T63143
Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
A2ti-2
T36433
A2ti-2 is a low affinity and selective inhibitor of the membrane-bound protein A2/S100A10 heterotetramer (A2t) (IC50 : 230 μM).A2ti-2 exhibits antiviral activity...
alpha-Mangostin
T1717
alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
ML188
T8371
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
(-)-α-Pinene
TN1202
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, actin...
L-Lysine hydrochloride
T8071
L-Lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, reducing diabetes-related illnesses, increasing cal...
MOSLOFLAVONE
T5779
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
Genkwanin
T6S0095
1. Genkwanin (Apigenin 7-methyl ether) exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transp...
5,7-Dihydroxychromone
T5S1805
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. ...
NGI-1
T7366
NGI-1 (ML414) is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.
Cephaeline hydrochloride
T3S1852
Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.
Tubacin
T6327
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
SID-852843
T73097
SID-852843 is a WNV NS2B-NS3 protease inhibitor with an IC50 value of 0.105 μM for WNV NS2B-NS3 protease.SID-852843 can be used for the study of viral infections...
(-)-Epicatechin gallate
T2732
(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins...
Retro-2
T8903
Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retro...
Sotirimod
T16913
Sotirimod(R850) is a novel immunomodulator with antitumor and antiviral activity for the study of actinic keratoses.
Dipotassium glycyrrhizinate
T5666
Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
Aspirin
T0005
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Asp...
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TargetMol