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Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Cat. No. Product name CAS No. Purity Chemical Structure
T5158 N-Desmethylclozapine 6104-71-8 98.45%
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T2244 ESI-09 263707-16-0 98.48%
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
T1307 Carmofur 61422-45-5 98.59%
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
T8328 STING agonist-1 702662-50-8 98.76%
STING agonist-1 is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
T12711 Retro-2 cycl 1429192-00-6 98.82%
Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 1...
T4S0999 (2S)-Isoxanthohumol 70872-29-6 98.82%
1. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol wi...
T2432 PD 169316 152121-53-4 98.83%
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
T8205 Norwogonin 4443-09-8 98.84%
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).
T11281L FGI-106 tetrahydrochloride 1149348-10-6 98.98%
FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetra...
T4492 Pocapavir 146949-21-5 99.01%
Pocapavir is an investigational enterovirus (EV) capsid inhibitor.
T0800 Danthron 117-10-2 99.03%
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
T3759 3,4-Dimethoxycinnamic acid 2316-26-9 99.07%
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effect...
T0005 Aspirin 50-78-2 99.09%
Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicyl...
T8498 EIDD-1931 3258-02-4 99.14%
EiDD1931 is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells,...
T1776 Plerixafor 110078-46-1 99.17%
Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
T0495 Aminothiazole 96-50-4 99.18%
Aminothiazole, a thyroid inhibitor, displays antibacterial activity.
TMO2787 Anthraquinone 84-65-1 99.2%
Anthraquinones are the main active constituents in herbs often used to relieve constipation.
T0122 Bergenin 477-90-7 99.43%
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
T1717 Alpha-Mangostin 6147-11-1 99.49%
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
TN2111 Prunin 529-55-5 99.52%
Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
N-Desmethylclozapine
T5158
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
ESI-09
T2244
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
Carmofur
T1307
Carmofur is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopat...
STING agonist-1
T8328
STING agonist-1 is a human-specific STING agonist,elicits antiviral activity against emerging Alphaviruses.
Retro-2 cycl
T12711
Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 1...
(2S)-Isoxanthohumol
T4S0999
1. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol wi...
PD 169316
T2432
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.
Norwogonin
T8205
Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).
FGI-106 tetrahydrochloride
T11281L
FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetra...
pocapavir
T4492
Pocapavir is an investigational enterovirus (EV) capsid inhibitor.
Danthron
T0800
Danthron is a natural product, regulates glucose, and lipid metabolism by activating AMPK.
3,4-Dimethoxycinnamic acid
T3759
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer found in Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effect...
Aspirin
T0005
Acetylsalicylic acid is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Acetylsalicyl...
EIDD-1931
T8498
EiDD1931 is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells,...
Plerixafor
T1776
Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
Aminothiazole
T0495
Aminothiazole, a thyroid inhibitor, displays antibacterial activity.
Anthraquinone
TMO2787
Anthraquinones are the main active constituents in herbs often used to relieve constipation.
Bergenin
T0122
Bergenin is a polyphenol, which is an effective antinarcotic agent with antioxidant action.
alpha-Mangostin
T1717
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
Prunin
TN2111
Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
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