T6914 |
Oclacitinib maleate
|
1640292-55-2
|
98%
|
|
Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which...
|
T3076 |
GLPG0634 analog
|
1206101-20-3
|
98%
|
|
GLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
|
T6104 |
Cerdulatinib hydrochloride
|
1369761-01-2
|
98%
|
|
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
|
T22416 |
RO495
|
1258296-60-4
|
98%
|
|
RO495, a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays
|
T1929 |
Filgotinib
|
1206161-97-8
|
98%
|
|
GLPG0634(filgotinib) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
|
T14687 |
Deucravacitinib
|
1609392-27-9
|
98%
|
|
BMS-986165 inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of ...
|
T12266 |
Ilginatinib
|
1239358-86-1
|
98%
|
|
Ilginatinib is a highly active and orally bioavailable inhibitor of JAK2.
|
T6S0923 |
Hypericin
|
548-04-9
|
98%
|
|
1. Hypericin has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoa...
|
T6020 |
Pacritinib
|
937272-79-2
|
98%
|
|
Pacritinib (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).
|
T6080 |
NVP-AEW541
|
475489-16-8
|
98%
|
|
NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
|
T12266L2 |
Ilginatinib hydrochloride
|
1239358-85-0
|
98%
|
|
Ilginatinib hydrochloride is a highly active and orally bioavailable inhibitor of JAK2.
|
T4391 |
Syk Inhibitor II (hydrochloride)
|
227449-73-2
|
98%
|
|
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
|
T4209 |
TAK-659 hydrochloride
|
1952251-28-3
|
98%
|
|
TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent ...
|
T2487 |
Cerdulatinib
|
1198300-79-6
|
98%
|
|
Cerdulatinib is an novel oral dual Syk/JAK inhibitor.
|
T2636 |
Decernotinib
|
944842-54-0
|
98%
|
|
Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.
|
T2360 |
Baricitinib phosphate
|
1187595-84-1
|
98%
|
|
Baricitinib phosphate is a selective orally bioavailable JAK1/JAK2 inhibitor.
|
T12266L |
Ilginatinib maleate
|
1354799-87-3
|
98%
|
|
Ilginatinib maleate is a highly active and orally bioavailable inhibitor of JAK2.
|
T71857 |
GTP-14564
|
34823-86-4
|
98%
|
|
GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressi...
|
T4210 |
SAR-20347
|
1450881-55-6
|
98%
|
|
SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
|
T2485 |
Baricitinib
|
1187594-09-7
|
98%
|
|
Baricitinib is an orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineoplastic activiti...
|