Tyrosine Kinases

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions. Tyrosine kinases are a subclass of protein kinase.The phosphate group is attached to the amino acid tyrosine on the protein. Tyrosine kinases are a subgroup of the larger class of protein kinases that attach phosphate groups to other amino acids (serine and threonine). Phosphorylation of proteins by kinases is an important mechanism in communicating signals within a cell (signal transduction) and regulating cellular activity, such as cell division.

Cat. No.	Product name	CAS No.	Purity
T6914	Oclacitinib maleate	1640292-55-2	98%
T6914	Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which...
T3076	GLPG0634 analog	1206101-20-3	98%
T3076	GLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
T6104	Cerdulatinib hydrochloride	1369761-01-2	98%
T6104	Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and S...
T22416	RO495	1258296-60-4	98%
T22416	RO495, a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays
T1929	Filgotinib	1206161-97-8	98%
T1929	GLPG0634(filgotinib) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.
T14687	Deucravacitinib	1609392-27-9	98%
T14687	BMS-986165 inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of ...
T12266	Ilginatinib	1239358-86-1	98%
T12266	Ilginatinib is a highly active and orally bioavailable inhibitor of JAK2.
T6S0923	Hypericin	548-04-9	98%
T6S0923	1. Hypericin has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoa...
T6020	Pacritinib	937272-79-2	98%
T6020	Pacritinib (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).
T6080	NVP-AEW541	475489-16-8	98%
T6080	NVP-AEW541, a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
T12266L2	Ilginatinib hydrochloride	1239358-85-0	98%
T12266L2	Ilginatinib hydrochloride is a highly active and orally bioavailable inhibitor of JAK2.
T4391	Syk Inhibitor II (hydrochloride)	227449-73-2	98%
T4391	Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chain...
T4209	TAK-659 hydrochloride	1952251-28-3	98%
T4209	TAK-659 is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent ...
T2487	Cerdulatinib	1198300-79-6	98%
T2487	Cerdulatinib is an novel oral dual Syk/JAK inhibitor.
T2636	Decernotinib	944842-54-0	98%
T2636	Decernotinib(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.
T2360	Baricitinib phosphate	1187595-84-1	98%
T2360	Baricitinib phosphate is a selective orally bioavailable JAK1/JAK2 inhibitor.
T12266L	Ilginatinib maleate	1354799-87-3	98%
T12266L	Ilginatinib maleate is a highly active and orally bioavailable inhibitor of JAK2.
T71857	GTP-14564	34823-86-4	98%
T71857	GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressi...
T4210	SAR-20347	1450881-55-6	98%
T4210	SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).
T2485	Baricitinib	1187594-09-7	98%
T2485	Baricitinib is an orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineoplastic activiti...