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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6S2140 β-Anhydroicaritin 38226-86-7 96.95%
β-Anhydroicaritin
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turn...
T3893 Forsythoside B 81525-13-5 96.52%
Forsythoside B
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
TN3849 Dihydrodehydrodiconiferyl alcohol 28199-69-1 96.50%
Dihydrodehydrodiconiferyl alcohol
Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
TN1511 Cleomiscosin A 76948-72-6 100.00%
Cleomiscosin A
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
T7889 C25-140 1358099-18-9 100%
C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
T22922 Lenalidomide hemihydrate 847871-99-2 100%
Lenalidomide hemihydrate
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
TJS1779 Protosappanin A 102036-28-2 100%
Protosappanin A
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
T0875 Acetylcysteine 616-91-1 100%
Acetylcysteine
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
T11484 GSK2593074A 1337531-06-2 100%
GSK2593074A
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T4319 Hispidol 5786-54-9 100%
Hispidol
Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelia...
T5785 MALTOTETRAOSE 34612-38-9
MALTOTETRAOSE
Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in th...
T3280 Clodronate disodium tetrahydrate 88416-50-6
Clodronate disodium tetrahydrate
Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.
TN1983 Neoisoastilbin 54141-72-9
Neoisoastilbin
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T2893 Muscone 541-91-3
Muscone
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T83628 TNF/IFNγ-IN-1 876013-29-5 98%
TNF/IFNγ-IN-1
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases...
T4637 R-7050 303997-35-5 98%
R-7050
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.
TQ0218 Deoxyandrographolide 79233-15-1 98%
Deoxyandrographolide
Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory media...
TN4583 Moringin 73255-40-0 98%
Moringin
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
T12985 SPD304 dihydrochloride 1049741-03-8 98%
SPD304 dihydrochloride
SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.
TN1599 Eburicoic acid 560-66-7 98%
Eburicoic acid
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in...
β-Anhydroicaritin
T6S2140
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turn...
Forsythoside B
T3893
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
Dihydrodehydrodiconiferyl alcohol
TN3849
Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
Cleomiscosin A
TN1511
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
C25-140
T7889
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
Lenalidomide hemihydrate
T22922
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
Protosappanin A
TJS1779
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
Acetylcysteine
T0875
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus th...
GSK2593074A
T11484
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
Hispidol
T4319
Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelia...
MALTOTETRAOSE
T5785
Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in th...
Clodronate disodium tetrahydrate
T3280
Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification.
Neoisoastilbin
TN1983
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
Muscone
T2893
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
TNF/IFNγ-IN-1
T83628
TNF/IFNγ-IN-1 (TGA) is a dual inhibitor of TNF and IFN-γ. TNF/IFNγ-IN-1 has potential antioxidant and anti-inflammatory activities for neurodegenerative diseases...
R-7050
T4637
R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.
Deoxyandrographolide
TQ0218
Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory media...
Moringin
TN4583
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
SPD304 dihydrochloride
T12985
SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.
Eburicoic acid
TN1599
Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in...
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TargetMol