TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.

Cat. No.	Product name	CAS No.	Purity
TN1132	Procyanidin A2	41743-41-3	98.78%
TN1132	Procyanidin A2 is a potential precursor of 5-(3',4'-dihydroxyphenyl)-γ-valerolactone, exhibits antioxidant, anti-inflammary, anti-hyperglycemia, and anti-type 2 ...
TN1579	Dihydrocucurbitacin B	13201-14-4	98.67%
TN1579	Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) is isolated from the roots of Cayaponia tayuya with anti-cancer activity.
TN1291	7,3',4'-Tri-O-methylluteolin	29080-58-8	98.66%
TN1291	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitry...
TN1475	Caulophyllogenin	52936-64-8	98.56%
TN1475	Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
T11742	K-7174	191089-59-5	98.55%
T11742	K-7174 is a novel cell adhesion inhibitor; inhibits the expression of vascular cell adhesion molecule-1 (VCAM-1) induced by either IL-1β or TNF-α.
T8692	(Rac)-Benpyrine	1333714-43-4	98.55%
T8692	(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.
T1125	Shikonin	517-89-5	98.54%
T1125	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-...
TN1520	Isoforskolin	64657-21-2	98.51%
TN1520	Isoforskolin is derived from Coleus forskohlii and reduces the secretion of TNF-α, IL-1β, IL-6 and IL-8 in human mononuclear leukocytes. Isoforskolin can be used...
TN2309	Withanolide A	32911-62-9	98.49%
TN2309	Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans.
T8440	LASSBio-1135	852453-71-5	98.43%
T8440	LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
T2879	Fisetin	528-48-3	98.31%
T2879	Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
T77494	TNF-α-IN-9	2054199-25-4	98.28%
T77494	TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.
T10865L	Cot inhibitor-1 hydrochloride	T10865L	98.26%
T10865L	Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
T3S0006	(E)-Ferulic acid methyl ester	22329-76-6	98.22%
T3S0006	(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
T2923	Apremilast	608141-41-9	98.13%
T2923	Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
T75174	Anti-inflammatory agent 42	877468-30-9	98.13%
T75174	Anti-inflammatory agent 42 has anti-inflammatory activity and inhibits the expression of TNF-α and IL-6 in LPS-stimulated macrophages.
TN1055	Licochalcone E	864232-34-8	98.09%
TN1055	Licochalcone E is a potential LXRβ agonist.
T61111	UCB-5307	1515887-44-1	98.02%
T61111	UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directl...
T9901	Adalimumab	331731-18-1	98.00%
T9901	Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
T5779	MOSLOFLAVONE	740-33-0	98%
T5779	MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.