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TNF

Tumor necrosis factor (TNF, cachexin, or cachectin; once named as tumor necrosis factor alpha or TNFα) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNF is a member of the TNF superfamily, consisting of various transmembrane proteins with a homologous TNF domain.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3S0006 (E)-Ferulic acid methyl ester 22329-76-6 98.22%
(E)-Ferulic acid methyl ester
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
T2923 Apremilast 608141-41-9 98.13%
Apremilast
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
TN1055 Licochalcone E 864232-34-8 98.09%
Licochalcone E
Licochalcone E is a potential LXRβ agonist.
T61111 UCB-5307 1515887-44-1 98.02%
UCB-5307
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directl...
T9901 Adalimumab 331731-18-1 98.00%
Adalimumab
Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
T5779 MOSLOFLAVONE 740-33-0 98%
MOSLOFLAVONE
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T5S1632 Barlerin 57420-46-9 98%
Barlerin
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
T5660 Menthone 10458-14-7 98%
Menthone
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
T7091 N-Formyl-Met-Leu-Phe 59880-97-6 98%
N-Formyl-Met-Leu-Phe
N-Formyl-Met-Leu-Phe (N-Formyl-MLF) (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).
TN1803 Isoscoparin 20013-23-4 97.95%
Isoscoparin
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
T60124 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 2379727-88-3 97.90%
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells t...
T60054 EJMC-1 397281-20-8 97.69%
EJMC-1
EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.
T5S0167 Atractylenolide I 73069-13-3 97.55%
Atractylenolide I
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T4423 LY 303511 hydrochloride 2070014-90-1 97.44%
LY 303511 hydrochloride
LY 303511 hydrochloride is a potent mTOR inhibitor
TN1373 α-Humulene 6753-98-6 97.18%
α-Humulene
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory e...
T6S2140 β-Anhydroicaritin 38226-86-7 96.95%
β-Anhydroicaritin
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turn...
T3893 Forsythoside B 81525-13-5 96.52%
Forsythoside B
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
TN3849 Dihydrodehydrodiconiferyl alcohol 28199-69-1 96.50%
Dihydrodehydrodiconiferyl alcohol
Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
TN1511 Cleomiscosin A 76948-72-6 100.00%
Cleomiscosin A
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
T7889 C25-140 1358099-18-9 100%
C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
(E)-Ferulic acid methyl ester
T3S0006
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) is a possible inhibitor of the mitogen activated phosphor kinase pathway, it could be a potential anti-inflam...
Apremilast
T2923
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
Licochalcone E
TN1055
Licochalcone E is a potential LXRβ agonist.
UCB-5307
T61111
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directl...
Adalimumab
T9901
Adalimumab (anti-TNF-alpha) is the first fully human recombinant IgG1 monoclonal antibody that specifically targets human TNF-alpha.
MOSLOFLAVONE
T5779
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
Barlerin
T5S1632
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
Menthone
T5660
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor ne...
N-Formyl-Met-Leu-Phe
T7091
N-Formyl-Met-Leu-Phe (N-Formyl-MLF) (fMLF) is a synthetic peptide that acts as an agonist at formyl peptide receptors (FPR; Ki = 0.8 pM).
Isoscoparin
TN1803
Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and tre...
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea
T60124
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells t...
EJMC-1
T60054
EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.
Atractylenolide I
T5S0167
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
LY 303511 hydrochloride
T4423
LY 303511 hydrochloride is a potent mTOR inhibitor
α-Humulene
TN1373
α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory e...
β-Anhydroicaritin
T6S2140
1. β-Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. β-Anhydroicaritin phytosomes can inhibit enhanced bone turn...
Forsythoside B
T3893
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response an...
Dihydrodehydrodiconiferyl alcohol
TN3849
Dihydrodehydrodiconiferyl alcohol is the methanolic extract of Liriodendron tulipifera[1].
Cleomiscosin A
TN1511
Cleomiscosin A is derived from Acer okamotoanum leaf and twig and shows inhibitory activity to TNF-α secretion of the mouse peritoneal macrophages. Cleomiscosin ...
C25-140
T7889
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
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TargetMol