T4185 |
Lavendustin C
|
125697-93-0
|
98%
|
|
Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
|
T24642 |
YH-306
|
1373764-75-0
|
98%
|
|
YH-306 is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
|
T6348 |
NVP-BHG712
|
940310-85-0
|
98%
|
|
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c...
|
T2358 |
ENMD-2076
|
934353-76-1
|
98%
|
|
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
|
T7371 |
1-Naphthyl PP1 hydrochloride
|
956025-47-1
|
98%
|
|
1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases v-Src
|
T7123 |
AMG-47a
|
882663-88-9
|
98%
|
|
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the lev...
|
T7345 |
7-Hydroxy-4H-chromen-4-one
|
59887-89-7
|
98%
|
|
7-Hydroxychromone is a Src kinase inhibitor (IC50 of <300 μM).
|
T14072 |
A-443654
|
552325-16-3
|
98%
|
|
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
T9650 |
AZ12672857
|
945396-55-4
|
98%
|
|
AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM. AZ12672857 inhibits cell proliferation of Src transfected 3T3 cells with IC50 of 2 nM and autophosphoryl...
|
T8499 |
ECF506
|
1914078-41-3
|
98%
|
|
eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)
|
TN1440 |
Beta-Hydroxyisovalerylshikonin
|
7415-78-3
|
98%
|
|
Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in ...
|
T12906 |
SI-2 hydrochloride
|
1992052-49-9
|
98%
|
|
SI-2 hydrochloride is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availabil...
|
T6997 |
SU6656
|
330161-87-0
|
98%
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
|
T2642 |
PD173074
|
219580-11-7
|
98%
|
|
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
|
T30855 |
CGP77675
|
234772-64-6
|
98%
|
|
CGP77675 is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and autophosphorylat...
|
T22552L |
AD57
|
1093380-42-7
|
98%
|
|
AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.
|
T11538 |
Hck-IN-1
|
1473404-51-1
|
98%
|
|
Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and...
|
T6028 |
PF 477736
|
952021-60-2
|
98%
|
|
PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
|
T6350 |
CHIR-124
|
405168-58-3
|
98%
|
|
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
|
T10927 |
Cyt-PTPε Inhibitor-1
|
428478-94-8
|
98%
|
|
Cyt-PTPε Inhibitor-1 is an inhibitor of cytosolic protein tyrosine phosphatase ε. Cyt-PTPε Inhibitor-1 blocks the dephosphorylation of c-Src and exhibits anti-os...
|