T13186L |
TL02-59 dihydrochloride
|
2415263-06-6
|
98%
|
|
TL02-59 dihydrochloride is an orally active inhibitor of Src-family kinase Fgr (IC50: 0.03 nM).
|
T15674 |
Tirbanibulin dihydrochloride
|
1038395-65-1
|
98%
|
|
Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
|
TN3139 |
5α-Hydroxycostic acid
|
132185-83-2
|
98%
|
|
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
|
T10206 |
A 419259
|
364042-47-7
|
98%
|
|
A 419259 is a pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family (IC50s: 9 nM, <3 nM and <3 nM for Src, Lck and Lyn).
|
T10784 |
CH6953755
|
2055918-71-1
|
98%
|
|
CH6953755 is a potent, orally active and selective inhibitor of YES1 kinase (IC50: 1.8 nM). It inhibits YES1 kinase, leading to antitumor activity against YES1 G...
|
T11752 |
Keap1-Nrf2-IN-1
|
2232112-72-8
|
98%
|
|
Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nr...
|
T14074 |
A-770041
|
869748-10-7
|
98%
|
|
A-770041 is selective and orally active Src-family Lck inhibitor, and the other Src family kinase involved in T-cell signaling. A-770041 is a 147 nM inhibitor of...
|
T10583 |
Bosutinib D8
|
T10583
|
98%
|
|
Bosutinib D8 is a deuterium-labeled Bosutinib. Bosutinib (SKI-606) is a dual Src/Abl inhibitor (IC50s: 1.2 nM/1 nM).
|
T35384 |
TPX-0046
|
2359650-19-2
|
98%
|
|
TPX-0046 is a RET inhibitor designed to overcome resistance to Selpercatinib and Pralsetinib.
|
T13186 |
TL02-59
|
1315330-17-6
|
98%
|
|
TL02-59 is a selective inhibitor of Fgr in Src-family kinase (IC50 = 0.03 nM). TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-5...
|
T13000 |
Src Inhibitor 3
|
2380027-49-4
|
98%
|
|
Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferati...
|
T9723 |
WAY-303290
|
323176-64-3
|
98%
|
|
WAY-303290 inhibits the pY binding site of tyrosine kinase p56lck SH2 domain.
|
T13156L |
TG 100572 Hydrochloride
|
867331-64-4
|
98%
|
|
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
|
T3593 |
Src Inhibitor 1
|
179248-59-0
|
98%
|
|
Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor.
|
T2372L |
Ponatinib Hydrochloride
|
1114544-31-8
|
98%
|
|
Ponatinib Hydrochloride is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2...
|
T6896 |
Tolimidone
|
41964-07-2
|
98%
|
|
MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
|
T6266 |
PP2
|
172889-27-9
|
98%
|
|
PP2 is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
|
T8976 |
PD-089828
|
179343-17-0
|
98%
|
|
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
|
T2603 |
Spebrutinib
|
1202757-89-8
|
98%
|
|
Spebrutinib is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.
|
T16750 |
Rigosertib
|
592542-59-1
|
98%
|
|
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
|