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Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Cat. No. Product name CAS No. Purity Chemical Structure
T12911 Sigma-1 receptor antagonist 2 1639220-15-7 98%
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).
T3198L PRE-084 hydrochloride 75136-54-8 98%
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
T22240 Amitriptyline 50-48-6 98%
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neurop...
T9244 σ1 Receptor antagonist-1 1204401-49-9 98%
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.
T1885 Siramesine hydrochloride 224177-60-0 98%
Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
T15393 Glycerol phenylbutyrate 611168-24-2 98%
Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T4229 S1RA hydrochloride 1265917-14-3 98%
S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
T12910 Sigma-1 receptor antagonist 1 1639220-19-1 98%
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity ...
T0678 Amitriptyline hydrochloride 549-18-8 98%
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T5027 Dimemorfan phosphate 36304-84-4 98%
Dimemorfan phosphate is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.
T4111 Blarcamesine hydrochloride 195615-84-0 98%
Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
T3597 Cutamesine dihydrochloride 165377-44-6 98%
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
T3198 Pre-084 138847-85-5 98%
PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
Sigma-1 receptor antagonist 2
T12911
Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).
PRE-084 hydrochloride
T3198L
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
Amitriptyline
T22240
Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties. Amitriptyline is widely used to treat depression and neurop...
σ1 Receptor antagonist-1
T9244
σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.
Siramesine hydrochloride
T1885
Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent antic...
Glycerol phenylbutyrate
T15393
Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
S1RA hydrochloride
T4229
S1RA HCl (E-52862 HCl) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki > 1000 nM).
Sigma-1 receptor antagonist 1
T12910
Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity ...
Amitriptyline hydrochloride
T0678
Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
Dimemorfan phosphate
T5027
Dimemorfan phosphate is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.
Blarcamesine hydrochloride
T4111
Anavex 2-73 is a Sigma-1 Receptor agonist (IC50: 860 nM).
Cutamesine dihydrochloride
T3597
Cutamesine dihydrochloride is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced...
Pre-084
T3198
PRE-084 hydrochloride is a high affinity, selective σ1 agonist.
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