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Reverse Transcriptase

A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases are used by retroviruses to replicate their genomes, by retrotransposon mobile genetic elements to proliferate within the host genome, by eukaryotic cells to extend the telomeres at the ends of their linear chromosomes, and by some non-retroviruses such as the hepatitis B virus, a member of the Hepadnaviridae, which are dsDNA-RT viruses.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78131 Emtricitabine triphosphate tetrasodium salt 1188407-46-6 98%
Emtricitabine triphosphate tetrasodium salt
Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of the phosphorylated anabolite (-)-Emtricitabine triphosphate, an active nucleoside rev...
T79579 DdUTP 84445-38-5 98%
ddUTP
ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) serves as a selective inhibitor of HIV and AMV reverse transcriptases with Ki values of 0.05 µM for HIV and 1 µM for...
T72461 EFdA-TP tetrasodium 2883783-00-2 98%
EFdA-TP tetrasodium
EFdA-TP tetrasodium, a potent nucleoside reverse transcriptase (RT) inhibitor, effectively halts RT-catalyzed DNA synthesis by acting as an immediate or delayed ...
T30791 Censavudine 634907-30-5 98%
Censavudine
Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus...
T11189 Emtricitabine S-oxide 152128-77-3 98%
Emtricitabine S-oxide
Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine su...
T1513 Telbivudine 3424-98-4 99.98%
Telbivudine
Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse ...
T3730 Methyl gallate 99-24-1 99.96%
Methyl gallate
Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
T1267 Abacavir 136470-78-5 99.94%
Abacavir
Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to th...
T6214 Emtricitabine 143491-57-0 99.93%
Emtricitabine
Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B ...
T1416 Zidovudine 30516-87-1 99.91%
Zidovudine
Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in...
T2409L Tenofovir Disoproxil Fumarate 202138-50-9 99.86%
Tenofovir Disoproxil Fumarate
Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor anal...
T2393 Efavirenz 154598-52-4 99.83%
Efavirenz
Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-N...
T2578 Didanosine 69655-05-6 99.81%
Didanosine
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
T3578 Pyridoxal phosphate 54-47-7 99.81%
Pyridoxal phosphate
Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved ...
T0110 Zalcitabine 7481-89-2 99.78%
Zalcitabine
Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, ...
T7212 Delavirdine mesylate 147221-93-0 99.75%
Delavirdine mesylate
Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T0753 Salicylanilide 87-17-2 99.68%
Salicylanilide
Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.
T1595 Nevirapine 129618-40-2 99.6%
Nevirapine
Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral...
T2551 Etravirine 269055-15-4 99.56%
Etravirine
Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutation...
T0153 Oltipraz 64224-21-1 99.56%
Oltipraz
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
Emtricitabine triphosphate tetrasodium salt
T78131
Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of the phosphorylated anabolite (-)-Emtricitabine triphosphate, an active nucleoside rev...
ddUTP
T79579
ddUTP (2′,3′-Dideoxyuridine-5′-triphosphate) serves as a selective inhibitor of HIV and AMV reverse transcriptases with Ki values of 0.05 µM for HIV and 1 µM for...
EFdA-TP tetrasodium
T72461
EFdA-TP tetrasodium, a potent nucleoside reverse transcriptase (RT) inhibitor, effectively halts RT-catalyzed DNA synthesis by acting as an immediate or delayed ...
Censavudine
T30791
Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus...
Emtricitabine S-oxide
T11189
Emtricitabine, a potent nucleoside reverse transcriptase inhibitor, is employed for managing HIV infection. Emtricitabine S-oxide, also known as Emtricitabine su...
Telbivudine
T1513
Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse ...
Methyl gallate
T3730
Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.
Abacavir
T1267
Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to th...
Emtricitabine
T6214
Emtricitabine (FTC) (FTC), a nucleoside reverse transcriptase inhibitor, exhibits inhibition activity against human immunodeficiency virus (HIV) and hepatitis B ...
Zidovudine
T1416
Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in...
Tenofovir Disoproxil Fumarate
T2409L
Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) is a pro-drug, fumaric acid salt form of tenofovir, a nucleoside reverse transcriptase inhibitor anal...
Efavirenz
T2393
Efavirenz (DMP 266) is a Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of efavirenz is as a Non-N...
Didanosine
T2578
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor analog of adenosine (IC50: 0.49 μM).
Pyridoxal phosphate
T3578
Pyridoxal phosphate (Vitamin B6 phosphate) is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved ...
Zalcitabine
T0110
Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, ...
Delavirdine mesylate
T7212
Delavirdine mesylate (BHAP-U 90152 (mesylate)) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Salicylanilide
T0753
Salicylanilide (2-Hydroxybenzanilide)s are a group of compounds with antiviral potency, antibacterial and antifungal activities.
Nevirapine
T1595
Nevirapine (NVP) is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral...
Etravirine
T2551
Etravirine (R165335) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutation...
Oltipraz
T0153
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
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TargetMol