T12474 |
PIM1-IN-1
|
1417630-95-5
|
98%
|
|
PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti...
|
T19611 |
(2R)-Octyl-α-hydroxyglutarate
|
1391194-67-4
|
98%
|
|
(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.
|
T15406 |
GNE-955
|
1527523-39-2
|
98%
|
|
GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
|
T15830 |
M-110
|
1395048-49-3
|
98%
|
|
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for PIM-3 (IC50=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC50s...
|
T1834 |
CX-6258
|
1202916-90-2
|
98%
|
|
CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.
|
T3989 |
SMI-16a
|
587852-28-6
|
97.06%
|
|
PIM1/2 Kinase Inhibitor VI, a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM...
|
T5093 |
Pim1/AKK1-IN-1
|
1093222-27-5
|
97.67%
|
|
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TN...
|
T27704 |
K00135
|
869650-21-5
|
97.88%
|
|
K00135 is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics.
|
T6148 |
CX-6258 hydrochloride
|
1353859-00-3
|
97.98%
|
|
CX-6258 HCl is an effective, orally efficacious Pim1/2/3 kinase inhibitor (IC50: 5/25/16 nM).
|
T10827 |
CK2/ERK8-IN-1
|
1085822-09-8
|
98.02%
|
|
CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1,...
|
TQ0201 |
Hispidulin
|
1447-88-7
|
98.53%
|
|
Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).
|
T14779 |
BRD7389
|
376382-11-5
|
99.17%
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
|
T3352 |
XL413
|
1169558-38-6
|
99.29%
|
|
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the a...
|
T2300 |
AZD1208
|
1204144-28-4
|
99.38%
|
|
AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
|
T3058 |
(Z)-SMI-4a
|
438190-29-5
|
99.44%
|
|
(Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
|
T2253 |
TCS PIM-1 1
|
491871-58-0
|
99.64%
|
|
TCS PIM-1 1(sc-204330) is a effective and specific ATP-competitive Pim-1 kianse inhibitor (IC50: 50 nM) , exhibits good specific over MEK1/MEK2 and Pim-2(IC50s >...
|
T8114 |
Quercetagetin
|
90-18-6
|
99.65%
|
|
Quercetagetin (6-Hydroxyquercetin) is the major flavonoid isolated from Citrus unshiu. It is a moderately potent and selective, cell-permeable pim-1 kinase inhib...
|
T12477 |
Uzansertib phosphate
|
2088852-47-3
|
99.75%
|
|
INCB053914 phosphate is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).
|
T6735 |
XL413 hydrochloride
|
2062200-97-7
|
99.82%
|
|
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exh...
|
T3078 |
SGI-1776
|
1025065-69-3
|
99.84%
|
|
SGI-1776 has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.
|