Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product name	CAS No.	Purity
T16357	DA-3003-1	383907-43-5	99.79%
T16357	DA-3003-1 (DA-3003-1) is a membrane-permeable, potent and selective Cdc25 dual specificity phosphatase inhibitor with antitumor activity that inhibits Cdc25B2, C...
T28410	PHPS1	314291-83-3	99.77%
T28410	PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-indepe...
T2068	(Rac)-LB-100	2061038-65-9	99.77%
T2068	LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation
T1927	CCT007093	176957-55-4	99.75%
T1927	CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).
T6459	Cyclosporine	79217-60-0	99.68%
T6459	Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.
T9174	Icerguastat	951441-04-6	99.67%
T9174	Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo...
T16762	RMC-4550	2172651-73-7	99.64%
T16762	RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
T13176	TNO155	1801765-04-7	99.63%
T13176	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with pote...
T4491	LMPTP INHIBITOR 1 hydrochloride	2310135-38-5	99.63%
T4491	LMPTP INHIBITOR 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase ( LMPTP ), with an IC 50 of 0.8 μM for LMPTP-A.
T25824	ML400	1908414-42-5	99.63%
T25824	ML400 (CID73050863) is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.
T3544	SHP099 hydrochloride	2200214-93-1	99.62%
T3544	SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.
TN1859	Licoflavone A	61153-77-3	99.61%
TN1859	Licoflavone A is a natural product isolated from the roots of Glycyrrhiza uralensis.
T4256	PTP1B-IN-2	1919853-46-5	99.58%
T4256	PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
T65128	Tartaric acid disodium dihydrate	6106-24-7	99.53%
T65128	Tartaric acid disodium dihydrate (Disodium L-(＋)-Tartrate Dihydrate) is commonly used as a buffer in molecular biology and cell culture.Tartaric acid disodium di...
TQ0032	Rosiptor	782487-28-9	99.53%
TQ0032	Rosiptor (AQX-1125) (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
TN2111	Prunin	529-55-5	99.52%
TN2111	Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate g...
T1654	Pentamidine isethionate	140-64-7	99.5%
T1654	Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T79607	H-NTPDase-IN-2	2939933-03-4	99.40%
T79607	h-NTPDase-IN-2 is a broad-spectrum NTPDase inhibitor that inhibits multiple h-NTPDas isoforms.
T7704	KY-226	1621673-53-7	99.4%
T7704	KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)
T0825	Ebselen	60940-34-3	99.38%
T0825	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimet...