Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research

Cat. No.	Product name	CAS No.	Purity
T3880	Silydianin	29782-68-1	99.02%
T3880	Silydianin exerts inhibition of UGT in human liver. Silydianin exerts inhibition of OATP1B1, OATP1B3 (unknown origin) expressed in HEK293 cells. Silydianin exert...
T7084	2-Bromo-4'-hydroxyacetophenone	2491-38-5	99.07%
T7084	PTP Inhibitor I is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain...
T4852	Trimyristin	555-45-3	99.11%
T4852	Within the cell, glyceryl trimyristate is primarily located in the membrane (predicted from logP) and adiposome. glyceryl trimyristate exists in all eukaryotes, ...
T9156	CDC25B-IN-2	134271-74-2	99.12%
T9156	BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.
T4308	F1063-0967	613225-56-2	99.15%
T4308	F1063-0967 is a Dual-specificity phosphatase 26 (DUSP26) inhibitor with an IC50 of 11.62 μM.
T14327	AS1949490	1203680-76-5	99.16%
T14327	AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes[1][2]. AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing in...
T20879	Tacrolimus monohydrate	109581-93-3	99.2%
T20879	Tacrolimus hydrate is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacro...
T8478	SC-43	1400989-25-4	99.26%
T8478	SC-43 is a potent and orally active agonist of SHP-1 (PTPN6). SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis, and with anti-fibrotic and ...
TCS1372	Atraric acid	4707-47-5	99.27%
TCS1372	Atraric acid derivatives as a new chemical lead structure for novel therapeutic compounds as AR antagonists, that can be used for prophylaxis or treatment of pro...
T6521	GSK 2830371	1404456-53-6	99.3%
T6521	GSK2830371 is an orally active, allosteric Wip1 phosphatase inhibitor with IC50 of 6 nM.
T2P2923	Stearic acid	57-11-4	99.31%
T2P2923	1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. ...
T7704	KY-226	1621673-53-7	99.4%
T7704	KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)
T4340	SPI-112	1051387-90-6	99.5%
T4340	SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competit...
T1210	Sodium etidronate	7414-83-7	99.5%
T1210	Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, eti...
T3804	Neomangiferin	64809-67-2	99.51%
T3804	Neomangiferin has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats. Neomangiferin and mangiferin inhibit tartrate-resistant a...
TN2111	Prunin	529-55-5	99.52%
TN2111	Prunin possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-re...
TQ0032	Rosiptor	782487-28-9	99.53%
TQ0032	Rosiptor (AQX-1125) is an orally-active and specific phosphatase SHIP1 activator with anti-inflammatory effects.
T4256	PTP1B-IN-2	1919853-46-5	99.58%
T4256	PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).
T3544	SHP099 hydrochloride	2200214-93-1	99.62%
T3544	SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.
T13176	TNO155	1801765-04-7	99.63%
T13176	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with pote...