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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1475 Caulophyllogenin 52936-64-8 98.56%
Caulophyllogenin
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
T3362 Eupatilin 22368-21-4 98.53%
Eupatilin
Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
T3710 XMD16-5 1345098-78-3 98.53%
XMD16-5
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted m...
T1941 GSK3787 188591-46-0 98.53%
GSK3787
GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
T2855 Icariin 489-32-7 98.49%
Icariin
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T8184 Fucosterol 17605-67-3 98.39%
Fucosterol
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
T4628 Seladelpar 851528-79-5 98.39%
Seladelpar
Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.
T8486 GW6471 880635-03-0 98.38%
GW6471
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMR...
T2879 Fisetin 528-48-3 98.31%
Fisetin
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
TQ0120 CDDO-Im 443104-02-7 98.3%
CDDO-Im
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
TN2290 Uvaol 545-46-0 98.27%
Uvaol
Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.
T19710 Ciglitazone 74772-77-3 98.23%
Ciglitazone
Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation o...
TQ0156 GW1929 196808-24-9 98.21%
GW1929
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
TN1055 Licochalcone E 864232-34-8 98.09%
Licochalcone E
Licochalcone E is a potential LXRβ agonist.
T77612 WAY-620472 686769-90-4 98.07%
WAY-620472
WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.
T68022L Sulotroban potassium 98.04%
Sulotroban potassium
Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.
T3403 Glabridin 59870-68-7 98.01%
Glabridin
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS und...
T8780 AMG131 315224-26-1 98.01%
AMG131
AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the...
T4S1545 Licarin B 51020-87-2 98%
Licarin B
1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
T5701 OPHIOPOGONIN D 945619-74-9 98%
OPHIOPOGONIN D
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
Caulophyllogenin
TN1475
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammat...
Eupatilin
T3362
Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.
XMD16-5
T3710
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted m...
GSK3787
T1941
GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).
Icariin
T2855
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
Fucosterol
T8184
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
Seladelpar
T4628
Seladelpar (MBX 8025) has been used in trials studying the treatment of Hyperlipidemia.
GW6471
T8486
GW6471 is an antagonist of PPARα with IC50 of 0.24 μ M. GW6471 enhances the binding affinity of the PPAR α ligand-binding domain to the co-repressor proteins SMR...
Fisetin
T2879
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
CDDO-Im
TQ0120
CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).
Uvaol
TN2290
Uvaol is present in olives and virgin olive oil with anti-inflammatory, anti-proliferative, and vasorelaxant activities.
Ciglitazone
T19710
Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation o...
GW1929
TQ0156
GW1929 is a potent PPAR-γ agonist (pKi: 8.84 for human PPAR-γ; pEC50s of 8.56 and 8.27 for human and murine PPAR-γ).
Licochalcone E
TN1055
Licochalcone E is a potential LXRβ agonist.
WAY-620472
T77612
WAY-620472 is a PPAR regulator that can be used to alter the lifespan of eukaryotes.
Sulotroban potassium
T68022L
Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.
Glabridin
T3403
Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS und...
AMG131
T8780
AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the...
Licarin B
T4S1545
1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
OPHIOPOGONIN D
T5701
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
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