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PPAR

In the field of molecular biology, the peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6689 T0070907 313516-66-4 99.36%
T0070907
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
T3954 Adelmidrol 1675-66-7 99.35%
Adelmidrol
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
T21587 Muraglitazar 331741-94-7 99.31%
Muraglitazar
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitr...
T68022 Sulotroban 72131-33-0 99.29%
Sulotroban
sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.
TN1525 Convallatoxin 508-75-8 99.27%
Convallatoxin
Convallatoxin is a natural product
T13289 EHP-101 1818428-24-8 99.22%
EHP-101
EHP-101 (VCE-​004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents di...
T63898 Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- 849150-59-0 99.18%
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo...
T6917 Oleuropein 32619-42-4 99.16%
Oleuropein
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
T21955 GQ-16 870554-67-9 99.12%
GQ-16
GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.
T12268 NTP42 2055599-51-2 99.09%
NTP42
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
TN1693 Glabrone 60008-02-8 99.08%
Glabrone
Glabrone shows antiviral activity against influenza virus.
T21764 MCC-555 161600-01-7 99.07%
MCC-555
MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.
T15821 LY518674 425671-29-0 99.06%
LY518674
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agon...
TN1126 Sakuranetin 2957-21-3 99%
Sakuranetin
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
TN7060 Methyl oleanonate 1721-58-0 98.99%
Methyl oleanonate
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
T28501 Ragaglitazar 222834-30-2 98.95%
Ragaglitazar
Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglit...
T7443 4'-Methoxychalcone 959-23-9 98.93%
4'-Methoxychalcone
4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
TN1990 Norathyriol 3542-72-1 98.93%
Norathyriol
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
T1238 Daidzein 486-66-8 98.84%
Daidzein
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestr...
T15945 MA-0204 2095128-17-7 98.83%
MA-0204
MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mou...
T0070907
T6689
T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.
Adelmidrol
T3954
Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.
Muraglitazar
T21587
Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitr...
Sulotroban
T68022
sulotroban is a TXA2 receptor antagonist that acts synergistically with iloprost to inhibit TXA2-dependent platelet activation.
Convallatoxin
TN1525
Convallatoxin is a natural product
EHP-101
T13289
EHP-101 (VCE-​004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents di...
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
T63898
Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo...
Oleuropein
T6917
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
GQ-16
T21955
GQ-16 is a partial agonist of PPARγ with a Ki of 160 nM. GQ-16 reduces adipogenic actions and promotes insulin Sensitization without weight gain.
NTP42
T12268
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM)
Glabrone
TN1693
Glabrone shows antiviral activity against influenza virus.
MCC-555
T21764
MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.
LY518674
T15821
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agon...
Sakuranetin
TN1126
Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects
Methyl oleanonate
TN7060
3-Oxoolean-12-en-28-oic acid methyl ester is a triterpenoid PPARγ agonist isolated from Pistacia with anticancer properties.
Ragaglitazar
T28501
Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglit...
4'-Methoxychalcone
T7443
4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.
Norathyriol
TN1990
Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Daidzein
T1238
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestr...
MA-0204
T15945
MA-0204 is a highly selective and orally available peroxisome proliferator-activated receptor δ (PPARδ) modulator (EC50s: 0.4 nM, 7.9 nM and 10 nM for human, mou...
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TargetMol