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PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.
Cat. No. Product name CAS No. Purity Chemical Structure
TN3922 Effusanin E 76470-15-0 98%
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
TN1458 Buddlejasaponin IV 139523-30-1 98%
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
T67844 RBN-3143 2360853-16-1 98%
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14...
TN4999 Serratenediol 2239-24-9 98%
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
TN3619 Cedrusin 75775-36-9 98%
Cedrusin shows a cytotoxic effect on A375 and HeLa cells.
T61189 E7016 902128-92-1 98%
E7016 is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
T12366 PARP14 inhibitor H10 2084811-68-5 98%
PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
TN2106 Protodeltonin 94992-08-2 98%
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhi...
TN4340 Ivangustin 14164-59-1 98%
Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines.
T5526 Glycoborinine 233279-39-5 98%
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
TN4028 Euchrestaflavanone B 87402-91-3 98%
Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanon...
TN1139 Dehydrocavidine 83218-34-2 98%
Dehydrocavidine has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well ...
T11992 Mefuparib hydrochloride 1449746-00-2 98%
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, su...
TN1880 Lucidenic acid B 95311-95-8 98%
Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal tr...
TN2511 Britannilactone diacetate 1286694-67-4 98%
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN4932 Sageone 142546-15-4 98%
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
TN1728 Hellebrigenin 465-90-7 98%
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. H...
TN1642 Ferruginol 514-62-5 98%
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
T16979 Talazoparib tosylate 1373431-65-2 98%
Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).
TN4637 Neogrifolin 23665-96-5 98%
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
Effusanin E
TN3922
Effusanin E shows antibacterial and anti-cancer activities, it significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p6...
Buddlejasaponin IV
TN1458
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
RBN-3143
T67844
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14...
Serratenediol
TN4999
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
Cedrusin
TN3619
Cedrusin shows a cytotoxic effect on A375 and HeLa cells.
E7016
T61189
E7016 is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
PARP14 inhibitor H10
T12366
PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
Protodeltonin
TN2106
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhi...
Ivangustin
TN4340
Ivangustin exhibits remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines.
Glycoborinine
T5526
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
Euchrestaflavanone B
TN4028
Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanon...
Dehydrocavidine
TN1139
Dehydrocavidine has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well ...
Mefuparib hydrochloride
T11992
Mefuparib hydrochloride induces apoptosis and possesses prominent anticancer activity in vitro and in vivo. Mefuparib hydrochloride (MPH) is an orally active, su...
Lucidenic acid B
TN1880
Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal tr...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Sageone
TN4932
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
Hellebrigenin
TN1728
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. H...
Ferruginol
TN1642
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
Talazoparib tosylate
T16979
Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).
Neogrifolin
TN4637
Neogrifolin is a potential candidate for osteosarcoma, it can induce concentration- and time-dependent suppression of proliferation and induce apoptosis in U2OS ...
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